Cover Image

Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia

Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling through activation of hypoxia-inducible factor 1α (HIF...

Full description

Saved in:
Bibliographic Details
Main Authors: García-Martín, Adela (Author) , Prados, María E. (Author) , Lastres-Cubillo, Isabel (Author) , Ponce-Diaz, Francisco J. (Author) , Cerero, Laura (Author) , Garrido-Rodriguez, Martin (Author) , Navarrete, Carmen (Author) , Pineda, Rafael (Author) , Rodríguez, Ana B. (Author) , Muñoz, Ignacio (Author) , Moya, Javier (Author) , Medeot, Antonella (Author) , Moreno, José A. (Author) , Chacón, Antonio (Author) , García-Revillo, José (Author) , Muñoz, Eduardo (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Journal of translational medicine
Year: 2024, Volume: 22, Pages: [2]-24
ISSN:1479-5876
DOI:10.1186/s12967-024-05748-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12967-024-05748-w
Get full text
Author Notes:Adela García-Martín, María E. Prados, Isabel Lastres-Cubillo, Francisco J. Ponce-Diaz, Laura Cerero, Martin Garrido-Rodríguez, Carmen Navarrete, Rafael Pineda, Ana B. Rodríguez, Ignacio Muñoz, Javier Moya, Antonella Medeot, José A. Moreno, Antonio Chacón, José García-Revillo and Eduardo Muñoz
Description
Summary:Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling through activation of hypoxia-inducible factor 1α (HIF-1α). This study delves into the pharmacological profile of VCE-004.8 (Etrinabdione) and evaluates its efficacy in a preclinical model of critical limb ischemia, with a focus on its potential as a PP2A/B55α activator to induce angiogenesis and arteriogenesis.
Item Description:Online veröffentlicht: 6. November 2024
Gesehen am 05.06.2025
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-024-05748-w

Similar Items