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Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated tha...

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Main Authors: Spotorno, Viviana G. (Author) , Roxo, Mariana (Author) , Wetterauer, Bernhard (Author) , Zabal, Osvaldo A. (Author) , Wink, Michael (Author)
Format: Article (Journal)
Language:English
Published: 05 January 2025
In: Fitoterapia
Year: 2025, Volume: 181, Pages: 1-7
ISSN:1873-6971
DOI:10.1016/j.fitote.2025.106380
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.fitote.2025.106380
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0367326X2500005X
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Author Notes:Viviana G. Spotorno, Mariana Roxo, Bernhard Wetterauer, Osvaldo A. Zabal, Michael Wink
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Summary:Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs.
Item Description:Online verfügbar: 05. Januar 2025
Gesehen am 06.06.2025
Physical Description:Online Resource
ISSN:1873-6971
DOI:10.1016/j.fitote.2025.106380

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