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Transcutaneous slowly depolarizing currents elicit pruritus in patients with atopic dermatitis

Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients with atopic dermatitis. C-nociceptor-specific e...

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Main Authors: Rukwied, Roman (Author) , Schnakenberg, Mark (Author) , Solinski, Hans Jürgen (Author) , Schmelz, Martin (Author) , Weisshaar, Elke (Author)
Format: Article (Journal)
Language:English
Published: October 2020
In: Acta dermato-venereologica
Year: 2020, Volume: 100, Issue: 17, Pages: 1-6
ISSN:1651-2057
DOI:10.2340/00015555-3658
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2340/00015555-3658
Verlag, lizenzpflichtig, Volltext: https://medicaljournalssweden.se/actadv/article/view/1817
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Author Notes:Roman Rukwied, Mark Schnakenberg, Hans Jürgen Solinkski, Martin Schmelz and Elke Weisshaar
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Summary:Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients with atopic dermatitis. C-nociceptor-specific electrical stimu?lation was applied to areas of eczema-affected and non-affected skin in 26 patients with atopic dermatitis. Single half-sine wave pulses (500 ms, 0.2?1 mA) induced itch in 9 patients in eczema-affected areas of the skin (numerical rating scale 5???1), but pain in control skin (numerical rating scale 6???1).Sinusoidal stimuli (4 Hz, 10 pulses, 0.025?0.4 mA) evoked itch in only 3 patients in eczema-affected areas of the skin but on delivering pulses for one minute (0.05?0.2 mA) 48% of the patients (n=?12) reported itch with numerical rating scale 4???1 in areas of eczema-affected skin. The number of patients reporting itch in eczema-affected areas of the skin increased with longer stimulation (p?
Item Description:Gesehen am 06.06.2025
Physical Description:Online Resource
ISSN:1651-2057
DOI:10.2340/00015555-3658

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