Phosphoinositide switches in cell physiology: from molecular mechanisms to disease
Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that represent low abundance components of biological membranes. Rather than serving as mere structural elements of lipid bilayers, they represent molecular switches for a broad range of biological processes, includi...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 February 2024
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| In: |
The journal of biological chemistry
Year: 2024, Volume: 300, Issue: 3, Pages: 1-16 |
| ISSN: | 1083-351X |
| DOI: | 10.1016/j.jbc.2024.105757 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jbc.2024.105757
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| Author Notes: | Fabio Lolicato, Walter Nickel, Volker Haucke, and Michael Ebner |
| Summary: | Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that represent low abundance components of biological membranes. Rather than serving as mere structural elements of lipid bilayers, they represent molecular switches for a broad range of biological processes, including cell signaling, membrane dynamics and remodeling, and many other functions. Here, we focus on the molecular mechanisms that turn phosphoinositides into molecular switches and how the dysregulation of these processes can lead to disease. |
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| Item Description: | Gesehen am 13.06.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1083-351X |
| DOI: | 10.1016/j.jbc.2024.105757 |