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Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra

Hydra head regeneration consists of hypostome/organizer and tentacle development, and involves Notch and Wnt/β-catenin signaling. Notch inhibition blocks hypostome/organizer regeneration, but not the appearance of the tentacle tissue. β-Catenin inhibition blocks tentacle, but not hypostome/organizer...

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Main Authors: Steichele, Mona (Author) , Sauermann, Lara (Author) , Pan, Qin (Author) , Moneer, Jasmin (Author) , Porte, Alexandra de la (Author) , Heß, Martin (Author) , Mercker, Moritz (Author) , Strube, Catharina (Author) , Flaswinkel, Heinrich (Author) , Jenewein, Marcell (Author) , Böttger, Angelika (Author)
Format: Article (Journal)
Language:English
Published: January 2025
In: Life science alliance
Year: 2025, Volume: 8, Issue: 1, Pages: 1-18
ISSN:2575-1077
DOI:10.26508/lsa.202403054
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.26508/lsa.202403054
Verlag, lizenzpflichtig, Volltext: https://www.life-science-alliance.org/content/8/1/e202403054
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Author Notes:Mona Steichele, Lara Sauermann, Qin Pan, Jasmin Moneer, Alexandra de la Porte, Martin Heß, Moritz Mercker, Catharina Strube, Heinrich Flaswinkel, Marcell Jenewein, Angelika Böttger
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Summary:Hydra head regeneration consists of hypostome/organizer and tentacle development, and involves Notch and Wnt/β-catenin signaling. Notch inhibition blocks hypostome/organizer regeneration, but not the appearance of the tentacle tissue. β-Catenin inhibition blocks tentacle, but not hypostome/organizer regeneration. Gene expression analyses during head regeneration revealed the Notch-promoting expression of HyWnt3, HyBMP2/4, and the transcriptional repressor genes CnGsc, Sp5, and HyHes, while blocking HyBMP5/8b and the c-fos-related gene HyKayak. β-Catenin promotes the expression of the tentacle specification factor HyAlx, but not of HyWnt3. This suggests HyWnt3 and HyBMP4 as parts of a hypostome/organizer gene module, and BMP5/8, HyAlx, and β-catenin as parts of a tentacle gene module. Notch then functions as an inhibitor of tentacle production to allow regeneration of a hypostome/head organizer. HyKayak is a candidate target gene for HvNotch-induced repressor genes. Inhibiting HyKayak attenuated the expression of HyWnt3. Polyps of Craspedacusta do not have tentacles and thus after head removal only regenerate a hypostome structure. Notch signaling was not needed for head regeneration in Craspedacusta, corroborating the idea of its requirement during Hydra head regeneration to harmonize two co-operating pattern-forming processes.
Item Description:Online veröffentlicht: 12. November 2024
Gesehen am 18.06.2025
Physical Description:Online Resource
ISSN:2575-1077
DOI:10.26508/lsa.202403054

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