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Sci-ModoM: a quantitative database of transcriptome-wide high-throughput RNA modification sites

We present Sci-ModoM, the first next-generation RNome database offering a holistic view of the epitranscriptomic landscape. Sci-ModoM has a simple yet powerful interface, underpinned by FAIR data principles, a standardized nomenclature, and interoperable formats, fostering the use of common standard...

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Main Authors: Boileau, Etienne (Author) , Wilhelmi, Harald (Author) , Busch, Anne (Author) , Cappannini, Andrea (Author) , Hildebrand, Andreas (Author) , Bujnicki, Janusz M (Author) , Dieterich, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 6 January 2025
In: Nucleic acids research
Year: 2025, Volume: 53, Issue: D1, Pages: 310-317
ISSN:1362-4962
DOI:10.1093/nar/gkae972
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/nar/gkae972
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Author Notes:Etienne Boileau, Harald Wilhelmi, Anne Busch, Andrea Cappannini, Andreas Hildebrand, Janusz M Bujnicki, Christoph Dieterich
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Summary:We present Sci-ModoM, the first next-generation RNome database offering a holistic view of the epitranscriptomic landscape. Sci-ModoM has a simple yet powerful interface, underpinned by FAIR data principles, a standardized nomenclature, and interoperable formats, fostering the use of common standards within the epitranscriptomics community. Sci-ModoM provides quantitative measurements per site and dataset, enabling users to assess confidence levels based on score, coverage, and stoichiometry. Data in Sci-ModoM is directly traceable to its sources. Users can Search and Compare over six million modifications across 156 datasets, Browse or download datasets, and retrieve metadata. A comparison tool offers a novel and unique opportunity to compare modifications site-wise across datasets, with the ability to securely upload and compare user data against latest published research. Sci-ModoM empowers researchers, including non-experts, to access a broad spectrum of recent quantitative RNA modification data, thereby enhancing the utility and impact of latest discoveries, and opening new avenues in biological and medical research.
Item Description:Online veröffentlicht: 5. November 2024
Gesehen am 25.06.2025
Physical Description:Online Resource
ISSN:1362-4962
DOI:10.1093/nar/gkae972

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