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Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study

Elevated levels of Endothelin-1 (ET-1), a vasoactive peptide, have been associated with adverse outcomes in neonates with congenital diaphragmatic hernia (CDH). However, the relationship between ET-1 levels and clinical outcomes remains poorly understood. This study aimed to investigate the kinetics...

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Main Authors: Lemloh, Lotte (Author) , de Vadder, Aster (Author) , Melaku, Tamene (Author) , Bo, Bartolomeo (Author) , Patel, Neil (Author) , Holdenrieder, Stefan (Author) , Müller, Andreas (Author) , Kipfmüller, Florian (Author)
Format: Article (Journal)
Language:English
Published: 21 March 2025
In: Respiratory research
Year: 2025, Volume: 26, Issue: 1, Pages: 1-11
ISSN:1465-993X
DOI:10.1186/s12931-025-03188-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12931-025-03188-8
Verlag, kostenfrei, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-025-03188-8
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Author Notes:Lotte Lemloh, Aster de Vadder, Tamene Melaku, Bartolomeo Bo, Neil Patel, Stefan Holdenrieder, Andreas Mueller and Florian Kipfmueller
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Summary:Elevated levels of Endothelin-1 (ET-1), a vasoactive peptide, have been associated with adverse outcomes in neonates with congenital diaphragmatic hernia (CDH). However, the relationship between ET-1 levels and clinical outcomes remains poorly understood. This study aimed to investigate the kinetics of ET-1 levels in CDH neonates from birth to 48 h postnatally and assess its association with clinical comorbidities, the need for extracorporeal membrane oxygenation (ECMO), and mortality.
Item Description:Gesehen am 10.07.2025
Physical Description:Online Resource
ISSN:1465-993X
DOI:10.1186/s12931-025-03188-8

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