Predictive value of renal shear wave elastography in liver cirrhosis: liver, pancreas and biliary tract
Background - In liver cirrhosis, prognosis is profoundly affected by renal function. This study evaluates the usefulness of renal stiffness measurement by point-shear wave elastography and renal perfusion by duplex. - Methods - In this case-control study, organ stiffness was quantified using point-s...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2025
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| In: |
Digestive and liver disease
Year: 2025, Volume: 57, Issue: 2, Pages: 512-518 |
| ISSN: | 1878-3562 |
| DOI: | 10.1016/j.dld.2024.10.018 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.dld.2024.10.018 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1590865824010624 
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| Author Notes: | Christian Hagel, Michael Hirth, Jan Bißbort, Andreas Teufel, Svetlana Hetjens, Matthias P. Ebert, Christoph Antoni |
| Summary: | Background - In liver cirrhosis, prognosis is profoundly affected by renal function. This study evaluates the usefulness of renal stiffness measurement by point-shear wave elastography and renal perfusion by duplex. - Methods - In this case-control study, organ stiffness was quantified using point-shear wave elastography and duplex sonography to calculate the arterial resistive (RI) and pulsatility indices (PI) in 123 patients, including patients with liver cirrhosis with (LC+A) and without ascites (LC-A) and patients without liver cirrhosis (NLC). - Results - PI and RI were significantly increased in LC-A and LC+A compared to NLC (p<0.001) and correlated with MELD and Child Pugh scores. Point-shear wave elastography showed significantly lower renal stiffness in LC+A compared to LC-A (p<0.01) and NLC (p<0.001). Renal stiffness correlated inversely with MELD and Child Pugh scores. Reduced renal stiffness, but not PI or RI, was associated with the presence of hepatorenal syndrome (p<0.001). Reduced renal stiffness was associated with an increased risk of death due to complications of liver cirrhosis within 3 years (p<0.01). - Conclusion - Point-shear wave elastography and duplex sonography correlate with progression of liver cirrhosis, but only shear wave elastography represents a valuable prognostic tool for hepatorenal syndrome and mortality in patients with liver cirrhosis. |
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| Item Description: | Online verfügbar: 28. Oktober 2024, Artikelversion: 24. Januar 2025 Gesehen am 10.07.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1878-3562 |
| DOI: | 10.1016/j.dld.2024.10.018 |