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Predictive value of renal shear wave elastography in liver cirrhosis: liver, pancreas and biliary tract

Background - In liver cirrhosis, prognosis is profoundly affected by renal function. This study evaluates the usefulness of renal stiffness measurement by point-shear wave elastography and renal perfusion by duplex. - Methods - In this case-control study, organ stiffness was quantified using point-s...

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Hauptverfasser: Hagel, Christian (VerfasserIn) , Hirth, Michael (VerfasserIn) , Bißbort, Jan (VerfasserIn) , Teufel, Andreas (VerfasserIn) , Hetjens, Svetlana (VerfasserIn) , Ebert, Matthias (VerfasserIn) , Antoni, Christoph Helmer (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 2025
In: Digestive and liver disease
Year: 2025, Jahrgang: 57, Heft: 2, Pages: 512-518
ISSN:1878-3562
DOI:10.1016/j.dld.2024.10.018
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.dld.2024.10.018
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1590865824010624
Volltext
Verfasserangaben:Christian Hagel, Michael Hirth, Jan Bißbort, Andreas Teufel, Svetlana Hetjens, Matthias P. Ebert, Christoph Antoni
Beschreibung
Zusammenfassung:Background - In liver cirrhosis, prognosis is profoundly affected by renal function. This study evaluates the usefulness of renal stiffness measurement by point-shear wave elastography and renal perfusion by duplex. - Methods - In this case-control study, organ stiffness was quantified using point-shear wave elastography and duplex sonography to calculate the arterial resistive (RI) and pulsatility indices (PI) in 123 patients, including patients with liver cirrhosis with (LC+A) and without ascites (LC-A) and patients without liver cirrhosis (NLC). - Results - PI and RI were significantly increased in LC-A and LC+A compared to NLC (p<0.001) and correlated with MELD and Child Pugh scores. Point-shear wave elastography showed significantly lower renal stiffness in LC+A compared to LC-A (p<0.01) and NLC (p<0.001). Renal stiffness correlated inversely with MELD and Child Pugh scores. Reduced renal stiffness, but not PI or RI, was associated with the presence of hepatorenal syndrome (p<0.001). Reduced renal stiffness was associated with an increased risk of death due to complications of liver cirrhosis within 3 years (p<0.01). - Conclusion - Point-shear wave elastography and duplex sonography correlate with progression of liver cirrhosis, but only shear wave elastography represents a valuable prognostic tool for hepatorenal syndrome and mortality in patients with liver cirrhosis.
Beschreibung:Online verfügbar: 28. Oktober 2024, Artikelversion: 24. Januar 2025
Gesehen am 10.07.2025
Beschreibung:Online Resource
ISSN:1878-3562
DOI:10.1016/j.dld.2024.10.018

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