Serum carnosinase 1 is not associated with insulin resistance or glucose metabolism in a type 1 diabetes cohort
Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 February 2025
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| In: |
Biomedicines
Year: 2025, Volume: 13, Issue: 2, Pages: 1-8 |
| ISSN: | 2227-9059 |
| DOI: | 10.3390/biomedicines13020366 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biomedicines13020366 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2227-9059/13/2/366 
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| Author Notes: | Jiedong Qiu, Benito A. Yard, Bernhard K. Krämer, Harry van Goor, Peter R. van Dijk and Aimo Kannt |
| Summary: | Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans. Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared. Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles (p > 0.05). Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort. |
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| Item Description: | Gesehen am 17.07.2025 |
| Physical Description: | Online Resource |
| ISSN: | 2227-9059 |
| DOI: | 10.3390/biomedicines13020366 |