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Serum carnosinase 1 is not associated with insulin resistance or glucose metabolism in a type 1 diabetes cohort

Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in...

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Main Authors: Qiu, Jiedong (Author) , Yard, Benito A. (Author) , Krämer, Bernhard (Author) , van Goor, Harry (Author) , van Dijk, Peter R. (Author) , Kannt, Aimo (Author)
Format: Article (Journal)
Language:English
Published: 5 February 2025
In: Biomedicines
Year: 2025, Volume: 13, Issue: 2, Pages: 1-8
ISSN:2227-9059
DOI:10.3390/biomedicines13020366
Online Access:kostenfrei
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Author Notes:Jiedong Qiu, Benito A. Yard, Bernhard K. Krämer, Harry van Goor, Peter R. van Dijk and Aimo Kannt
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Summary:Background/Objectives: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans. Methods: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared. Results: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles (p > 0.05). Conclusions: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort.
Item Description:Gesehen am 17.07.2025
Physical Description:Online Resource
ISSN:2227-9059
DOI:10.3390/biomedicines13020366

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