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HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene.

Familial clustering of autoimmune thyroid diseases has led to studies of their association with human major histocompatibility complex (MHC) class II genes. One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak and is contradicted by other reports. On...

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Main Authors: Kong, Yi-chi M. (Author) , Lomo, Lesley C. (Author) , Motte, Reinhard W. (Author) , Giraldo, Alvaro A. (Author) , Baisch, Jean (Author) , Strauß, Gudrun (Author) , Hämmerling, Günter J. (Author) , David, Chella S. (Author)
Format: Article (Journal)
Language:English
Published: September 01 1996
In: Journal of experimental medicine
Year: 1996, Volume: 184, Issue: 3, Pages: 1167-1172
ISSN:1540-9538
DOI:10.1084/jem.184.3.1167
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1084/jem.184.3.1167
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Author Notes:byYi-chi M. Kong, Lesley C. Lomo, Reinhard W. Motte,Alvaro A. Giraldo, Jean Baisch, Gudrun Strauss, GünterJ. Hämmerling, and Chella S. Davids
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Summary:Familial clustering of autoimmune thyroid diseases has led to studies of their association with human major histocompatibility complex (MHC) class II genes. One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak and is contradicted by other reports. On the other hand, murine experimental autoimmune thyroiditis (EAT), a model for HT, presents a clear linkage with MHC class II. Moreover, it is inducible with thyroglobulin (Tg), the common autoantigen in either species. Immunization of HLA-DRB1* 0301 (DR3) transgenic mice with mouse or human Tg resulted in severe thyroiditis. In contrast, transgenic mice expressing the HLA-DRB1*1502 (DR2) gene were resistant to EAT. Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
Item Description:Gesehen am 23.07.2025
Physical Description:Online Resource
ISSN:1540-9538
DOI:10.1084/jem.184.3.1167

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