From smoking to vaping: the motivation for e-cigarette use at the neurobiological level : a functional magnetic resonance imaging study
Electronic cigarettes (e-cigarettes) are considered a potential aid for smoking cessation. This study investigates the neurobiological mechanisms underlying the motivational properties of e-cigarettes compared to tobacco cigarettes and provides insights into their addictive potential and implication...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2025
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| In: |
Nicotine & tobacco research
Year: 2025, Volume: 27, Issue: 7, Pages: 1236-1246 |
| ISSN: | 1469-994X |
| DOI: | 10.1093/ntr/ntae273 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ntr/ntae273
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| Author Notes: | Nadja Grundinger MSc, Marike Andreas MSc, Valerie Lohner PhD, Sven Schneider PhD, Ute Mons PhD, Sabine Vollstädt-Klein PhD |
| Summary: | Electronic cigarettes (e-cigarettes) are considered a potential aid for smoking cessation. This study investigates the neurobiological mechanisms underlying the motivational properties of e-cigarettes compared to tobacco cigarettes and provides insights into their addictive potential and implications for smoking cessation.The study included 47 daily e-cigarette users, the majority of whom were former smokers (n = 43), and 28 nicotine-naïve participants as controls. Among the e-cigarette users, 32 individuals currently used e-cigarettes exclusively, while 15 also used tobacco cigarettes (dual users). Functional magnetic resonance imaging was used to examine anticipatory brain activation to reward-predictive stimuli for money, e-liquid, or tobacco cigarettes, as well as the instrumental response to obtain each reward.Exclusive e-cigarette users demonstrated increased activation in limbic regions, for example, the nucleus accumbens, during the anticipation of e-liquid and money over tobacco cigarettes. Prefrontal regions showed greater activation during the anticipation of money compared to e-liquid or tobacco cigarettes. Dual users showed greater activation for money compared to tobacco cigarettes in the hippocampal limbic system. No significant differences were observed in the anticipation of e-liquid and tobacco cigarettes among dual users.E-cigarettes are perceived as equally rewarding as money, highlighting their addictive potential. Among exclusive e-cigarette users, money and e-liquid have stronger motivational properties than tobacco cigarettes (even among former smokers), suggesting that e-cigarettes may be an effective tool for tobacco cessation. The comparable appeal of e-liquid and tobacco cigarettes among dual users may suggest that a complete switch to e-cigarettes may be more effective for smoking cessation.It is important to understand the motivational properties of e-cigarettes, particularly compared to traditional tobacco products. E-cigarettes with little or no addictive potential might not be effective as a substitute for tobacco cigarettes; however, a high addictive potential would, conversely, pose a risk to nonsmokers. Our data suggest that e-cigarettes have a sufficiently high addictive potential to make them an attractive alternative for smokers, especially if they switch completely from tobacco to e-cigarettes. |
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| Item Description: | Online veröffentlicht: 21. November 2024 Gesehen am 28.07.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1469-994X |
| DOI: | 10.1093/ntr/ntae273 |