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In vivo endocultivation of CAD/CAM hybrid scaffolds in the omentum majus in miniature pigs

Purpose - Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus ove...

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Hauptverfasser: Wagner, Juliane (VerfasserIn) , Bayer, Lennart (VerfasserIn) , Loger, Klaas (VerfasserIn) , Acil, Yahya (VerfasserIn) , Kurz, Sascha (VerfasserIn) , Spille, Johannes (VerfasserIn) , Ahlhelm, Matthias (VerfasserIn) , Ingwersen, Lena-Christin (VerfasserIn) , Jonitz-Heincke, Anika (VerfasserIn) , Sedaghat, Sam (VerfasserIn) , Wiltfang, Jörg (VerfasserIn) , Naujokat, Hendrik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 2024
In: Journal of cranio-maxillofacial surgery
Year: 2024, Jahrgang: 52, Heft: 11, Pages: 1259-1266
ISSN:1878-4119
DOI:10.1016/j.jcms.2024.04.012
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jcms.2024.04.012
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1010518224001628
Volltext
Verfasserangaben:Juliane Wagner, Lennart Bayer, Klaas Loger, Yahya Acil, Sascha Kurz, Johannes Spille, Matthias Ahlhelm, Lena-Christin Ingwersen, Anika Jonitz-Heincke, Sam Sedaghat, Jörg Wiltfang, Hendrik Naujokat
Beschreibung
Zusammenfassung:Purpose - Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus over 6 months and the extent to which rhBMP-2 as a growth factor, alone or combined with a hydrogel, affects regeneration. - Materials and methods - In this animal study, 10 Göttingen minipigs each had one scaffold implanted in the greater omentum. Five animals had scaffolds loaded with a collagen hydrogel and rhBMP-2, and the other five animals (control group) had scaffolds loaded with rhBMP-2 only. Fluorochrome injections and computed tomography (CT) were performed regularly. After 6 months, the animals were euthanized, and samples were collected for microCT and histological evaluations. - Results - Fluorescent and light microscopic and a CT morphological density evaluation showed continuous bone growth until week 16 in both groups. Regarding the ratio of bone attachment to the Zr02 support struts, the rhBMP-2 loaded collagen hydrogel group showed with 63% a significantly higher attachment (p > 0.001) than the rhBMP-2 control group (49%). - Conclusion - In this study, bone growth was induced in all omentum majus specimens until post-operative week 16. Furthermore, hydrogel and rhBMP-2 together resulted in better bone-scaffold integration than rhBMP-2 alone. Further studies should investigate whether implantation of the scaffolds in the jaw after an appropriate period of bone regeneration leads to a stable situation and the desired results.
Beschreibung:Gesehen am 28.07.2025
Beschreibung:Online Resource
ISSN:1878-4119
DOI:10.1016/j.jcms.2024.04.012

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