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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lyso...

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Main Authors: Fang, Lipao (Author) , Lin, Ching-Hsin (Author) , Medlej, Yasser (Author) , Zhao, Renping (Author) , Chang, Hsin-Fang (Author) , Guo, Qilin (Author) , Wu, Zhonghao (Author) , Su, Yixun (Author) , Zhao, Na (Author) , Gobbo, Davide (Author) , Wyatt, Amanda (Author) , Wahl, Vanessa (Author) , Fiore, Frédéric (Author) , Tu, Szu-Min (Author) , Boehm, Ulrich (Author) , Huang, Wenhui (Author) , Bian, Shan (Author) , Agarwal, Amit (Author) , Lauterbach, Marcel A. (Author) , Yi, Chenju (Author) , Niu, Jianqin (Author) , Scheller, Anja (Author) , Kirchhoff, Frank (Author) , Bai, Xianshu (Author)
Format: Article (Journal)
Language:English
Published: 30 January 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-10
ISSN:2041-1723
DOI:10.1038/s41467-025-56484-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-56484-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-56484-8
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Author Notes:Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff & Xianshu Bai
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Summary:Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in the number or branching of OPCs reduces these contacts, which is associated with lysosome accumulation and altered metabolism in neurons and more senescent neurons with age. A similar reduction in OPC branching and neuronal lysosome accumulation is seen in an early-stage mouse model of Alzheimer’s disease. Our findings have implications for the prevention of age-related pathologies and the treatment of neurodegenerative diseases.
Item Description:Gesehen am 04.08.2025
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-56484-8

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