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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lyso...

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Hauptverfasser: Fang, Lipao (VerfasserIn) , Lin, Ching-Hsin (VerfasserIn) , Medlej, Yasser (VerfasserIn) , Zhao, Renping (VerfasserIn) , Chang, Hsin-Fang (VerfasserIn) , Guo, Qilin (VerfasserIn) , Wu, Zhonghao (VerfasserIn) , Su, Yixun (VerfasserIn) , Zhao, Na (VerfasserIn) , Gobbo, Davide (VerfasserIn) , Wyatt, Amanda (VerfasserIn) , Wahl, Vanessa (VerfasserIn) , Fiore, Frédéric (VerfasserIn) , Tu, Szu-Min (VerfasserIn) , Boehm, Ulrich (VerfasserIn) , Huang, Wenhui (VerfasserIn) , Bian, Shan (VerfasserIn) , Agarwal, Amit (VerfasserIn) , Lauterbach, Marcel A. (VerfasserIn) , Yi, Chenju (VerfasserIn) , Niu, Jianqin (VerfasserIn) , Scheller, Anja (VerfasserIn) , Kirchhoff, Frank (VerfasserIn) , Bai, Xianshu (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 30 January 2025
In: Nature Communications
Year: 2025, Jahrgang: 16, Pages: 1-10
ISSN:2041-1723
DOI:10.1038/s41467-025-56484-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-56484-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-56484-8
Volltext
Verfasserangaben:Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff & Xianshu Bai
Beschreibung
Zusammenfassung:Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in the number or branching of OPCs reduces these contacts, which is associated with lysosome accumulation and altered metabolism in neurons and more senescent neurons with age. A similar reduction in OPC branching and neuronal lysosome accumulation is seen in an early-stage mouse model of Alzheimer’s disease. Our findings have implications for the prevention of age-related pathologies and the treatment of neurodegenerative diseases.
Beschreibung:Gesehen am 04.08.2025
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-56484-8

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