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Reply to “Improving Brain-Gut Studies in Crohn’s Disease: Methodological Considerations”

We greatly appreciate the authors’ comments regarding our previous article and agree that more research is urgently needed to increase our understanding of brain-gut interactions in Inflammatory Bowel Diseases (IBD).The approach chosen in our study examined unprovoked brain activity with the aim to...

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Bibliographic Details
Main Authors: Thomann, Anne K. (Author) , Wolf, Robert Christian (Author)
Format: Article (Journal) Editorial
Language:English
Published: July 2025
In: Inflammatory bowel diseases
Year: 2025, Volume: 31, Issue: 7, Pages: 2049-2050
ISSN:1536-4844
DOI:10.1093/ibd/izaf051
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ibd/izaf051
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/ibdjournal/article/31/7/2049/8075163
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Author Notes:Anne Kerstin Thomann, MD and Robert Christian Wolf, MD, PhD
Description
Summary:We greatly appreciate the authors’ comments regarding our previous article and agree that more research is urgently needed to increase our understanding of brain-gut interactions in Inflammatory Bowel Diseases (IBD).The approach chosen in our study examined unprovoked brain activity with the aim to find general differences between different disease states of Crohn’s Disease and associations that might help to explain neuropsychiatric symptoms. However, we fully agree that resting-state functional magnetic resonance imaging (rs-fMRI) can only capture certain aspects of brain activity, specifically those occurring at rest, rather than under experimental conditions with external task demands. While task-based paradigms can undoubtedly provide a more dynamic and functional representation of neural capacities and disturbances, there is no general consensus on the optimal tasks for addressing specific research questions. Yet, future research could start by implementing tasks commonly used in depression or anxiety research,1 preferably in longitudinal settings as suggested by the authors. Also, the combination of rs- and task-based fMRI seems promising in order to detect shared network dysfunctions.
Item Description:Online veröffentlicht: 13. März 2025
Gesehen am 07.08.2025
Physical Description:Online Resource
ISSN:1536-4844
DOI:10.1093/ibd/izaf051

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