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Difficult-to-treat pathogens significantly reduce infection resolution in periprosthetic joint infections

Periprosthetic joint infection (PJI) is a feared complication after arthroplasty. Our hypothesis was that PJI caused by difficult-to-treat (DTT) pathogens has a worse outcome compared with non-DTT PJI. Routine clinical data on 77 consecutive patients with confirmed PJI treated with 2-stage exchange...

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Main Authors: Wimmer, Matthias Dominik (Author) , Hischebeth, Gunnar T. R. (Author) , Randau, Thomas M. (Author) , Gathen, Martin (Author) , Schildberg, Frank A. (Author) , Fröschen, Frank S. (Author) , Kohlhof, Hendrik (Author) , Gravius, Sascha (Author)
Format: Article (Journal)
Language:English
Published: October 2020
In: Diagnostic microbiology and infectious disease
Year: 2020, Volume: 98, Issue: 2, Pages: 1-5
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2020.115114
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.diagmicrobio.2020.115114
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0732889320304910
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Author Notes:Matthias D. Wimmer, Gunnar T. R. Hischebeth, Thomas M. Randau, Martin Gathen, Frank A. Schildberg, Frank S. Fröschen, Hendrik Kohlhof, Sascha Gravius
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Summary:Periprosthetic joint infection (PJI) is a feared complication after arthroplasty. Our hypothesis was that PJI caused by difficult-to-treat (DTT) pathogens has a worse outcome compared with non-DTT PJI. Routine clinical data on 77 consecutive patients with confirmed PJI treated with 2-stage exchange arthroplasty were placed in DTT and non-DTT PJI groups and analyzed. The main outcome variable was that the patient was definitively free of infection after 2 years. We found definitive infection resolution in 31 patients in the DTT group (68.9%) and 28 patients (87.5%) in the non-DTT group (P < 0.05). The necessity for revision surgery until assumed resolution of infection was significantly more frequent in the DTT group with 4.72 ± 3.03 operations versus 2.41 ± 3.02 operations in the non-DTT group (P < 0.05). PJI caused by DTT bacteria is associated with significantly higher numbers of revision operations and significantly inferior definitive infection resolution.
Item Description:Online verfügbar: 20. Juni 2020
Gesehen am 07.08.2025
Physical Description:Online Resource
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2020.115114

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