Difficult-to-treat pathogens significantly reduce infection resolution in periprosthetic joint infections
Periprosthetic joint infection (PJI) is a feared complication after arthroplasty. Our hypothesis was that PJI caused by difficult-to-treat (DTT) pathogens has a worse outcome compared with non-DTT PJI. Routine clinical data on 77 consecutive patients with confirmed PJI treated with 2-stage exchange...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2020
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| In: |
Diagnostic microbiology and infectious disease
Year: 2020, Jahrgang: 98, Heft: 2, Pages: 1-5 |
| ISSN: | 1879-0070 |
| DOI: | 10.1016/j.diagmicrobio.2020.115114 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.diagmicrobio.2020.115114 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0732889320304910 
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| Verfasserangaben: | Matthias D. Wimmer, Gunnar T. R. Hischebeth, Thomas M. Randau, Martin Gathen, Frank A. Schildberg, Frank S. Fröschen, Hendrik Kohlhof, Sascha Gravius |
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| 520 | |a Periprosthetic joint infection (PJI) is a feared complication after arthroplasty. Our hypothesis was that PJI caused by difficult-to-treat (DTT) pathogens has a worse outcome compared with non-DTT PJI. Routine clinical data on 77 consecutive patients with confirmed PJI treated with 2-stage exchange arthroplasty were placed in DTT and non-DTT PJI groups and analyzed. The main outcome variable was that the patient was definitively free of infection after 2 years. We found definitive infection resolution in 31 patients in the DTT group (68.9%) and 28 patients (87.5%) in the non-DTT group (P < 0.05). The necessity for revision surgery until assumed resolution of infection was significantly more frequent in the DTT group with 4.72 ± 3.03 operations versus 2.41 ± 3.02 operations in the non-DTT group (P < 0.05). PJI caused by DTT bacteria is associated with significantly higher numbers of revision operations and significantly inferior definitive infection resolution. | ||
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| 650 | 4 | |a Difficult-to-treat | |
| 650 | 4 | |a DTT | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Periprosthetic joint infection | |
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