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Dual antiplatelet pre-treatment with aspirin and ticagrelor in ACS patients undergoing unplanned aortocoronary bypass surgery

Major bleedings following coronary artery bypass grafting (CABG) have significant implications on outcomes in acute coronary syndrome (ACS) patients. Owing fears of fatal bleedings in case of urgent CABG, current guidelines recommend a cessation of P2Y12 receptor antagonists (P2Y12-RA) before cardia...

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Main Authors: Salbach, Christian (Author) , Yildirim, Mustafa (Author) , Gulba, Rebecca (Author) , Milles, Barbara Ruth (Author) , Biener, Moritz (Author) , Müller-Hennessen, Matthias (Author) , Hund, Hauke (Author) , Frey, Norbert (Author) , Giannitsis, Evangelos (Author)
Format: Article (Journal)
Language:English
Published: June 2025
In: Clinical research in cardiology
Year: 2025, Volume: 114, Issue: 6, Pages: 772-782
ISSN:1861-0692
DOI:10.1007/s00392-025-02629-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00392-025-02629-0
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00392-025-02629-0
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Author Notes:Christian Salbach, Mustafa Yildirim, Rebecca Gulba, Barbara Ruth Milles, Moritz Biener, Matthias Mueller-Hennessen, Hauke Hund, Norbert Frey, Evangelos Giannitsis
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Summary:Major bleedings following coronary artery bypass grafting (CABG) have significant implications on outcomes in acute coronary syndrome (ACS) patients. Owing fears of fatal bleedings in case of urgent CABG, current guidelines recommend a cessation of P2Y12 receptor antagonists (P2Y12-RA) before cardiac surgery and opt against routine pre-treatment with a P2Y12-RA before coronary angiography (CA). However, sparse information exists outside randomized trials on the frequency of urgent CABG and the consequences of inappropriately long cessation of P2Y12-RA treatment in patients presenting with ACS.
Item Description:Online verfügbar: 12. März 2025
Gesehen am 08.08.2025
Physical Description:Online Resource
ISSN:1861-0692
DOI:10.1007/s00392-025-02629-0

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