Transition-metal catalyzed, thermally driven [2π+2π]-cycloadditions of olefins and alkynes
The [2+2]-cycloaddition of olefins and alkynes stands out as a versatile and atom-economical strategy for synthesizing cyclobutane and cyclobutene building blocks, which are challenging to access through other synthetic methods. While photochemical approaches have traditionally dominated this field,...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 1, 2025
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| In: |
European journal of organic chemistry
Year: 2025, Volume: 28, Issue: 13, Pages: 1-26 |
| ISSN: | 1099-0690 |
| DOI: | 10.1002/ejoc.202401403 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ejoc.202401403 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202401403 
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| Author Notes: | Leif E. Hertwig, Felix J. Becker, and Dragoş-Adrian Roşca |
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| 520 | |a The [2+2]-cycloaddition of olefins and alkynes stands out as a versatile and atom-economical strategy for synthesizing cyclobutane and cyclobutene building blocks, which are challenging to access through other synthetic methods. While photochemical approaches have traditionally dominated this field, thermally-driven methods employing transition metals offer distinct advantages, including decreased reliance on pre-functionalized substrates and improved scalability. This review explores the underlying principles of metal-catalyzed [2+2]-cycloadditions and highlights recent advances in thermally-driven approaches for the efficient synthesis of cyclobutane and cyclobutene frameworks. Particular attention is given to electronically unbiased substrates, which remain a significant challenge for photochemical approaches. | ||
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