Inhibition of interleukin-8 synthesis by intraarticular methotrexate therapy in patientes with rheumatoid arthritis
5 Patients with definite RA and knee effusions under constant doses of DMARD therapy were treated with up to 6 intraarticular injections of 10mg methotrexate (MTX) every 3 to 7 days. A matched randomized control group who received a single i.a. injection of 40mg triamcinolone hexacetonide (TC) was m...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 1998
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| In: |
Zeitschrift für Rheumatologie
Year: 1998, Volume: 57, Issue: 2, Pages: 95-100 |
| ISSN: | 1435-1250 |
| DOI: | 10.1007/s003930050066 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s003930050066
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| Author Notes: | I.K. Gao, C. Leins, H. Bohlen, B. Heilig, E.-M. Lemmel |
| Summary: | 5 Patients with definite RA and knee effusions under constant doses of DMARD therapy were treated with up to 6 intraarticular injections of 10mg methotrexate (MTX) every 3 to 7 days. A matched randomized control group who received a single i.a. injection of 40mg triamcinolone hexacetonide (TC) was monitored according to the same protocol. The intraarticular granulocyte counts and IL-8 levels decreased in all MTX treated patients on day 10-13 and stayed low in those patients who could be re-evaluated after 13 weeks. Compared to the IL-8 levels, the other tested cytokine levels showed only minor changes on day 10-13. There was no need for re-injection in the TC group during the 13 week study phase. |
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| Item Description: | Zusammenfassung in deutscher und englischer Sprache Gesehen am 13.08.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1435-1250 |
| DOI: | 10.1007/s003930050066 |