A novel face of immediate-early genes: transcriptional operations dominated by c-Jun and Jun D proteins in neurons following axotomy and during regenerative efforts
The investigation of immediate-early genes (IEGs) in neurons and glial cells represents a new research area in neurobiology. IEGs are rapidly expressed by transsynaptic stimulation or transmembranous information transfer. A substantial number of IEGs encode for transcription factors (TF) which are i...
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| Main Authors: | , , , , , , , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
1995
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| In: |
Immediate-early genes in the central nervous system
Year: 1995, Pages: 78-103 |
| DOI: | 10.1007/978-3-642-79562-6_5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/978-3-642-79562-6_5
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| Author Notes: | T. Herdegen, S. Brecht, C.E. Fiallos-Estrada, H. Wickert, F. Gillardon, S. Voss, R. Bravo, M. Zimmermann |
| Summary: | The investigation of immediate-early genes (IEGs) in neurons and glial cells represents a new research area in neurobiology. IEGs are rapidly expressed by transsynaptic stimulation or transmembranous information transfer. A substantial number of IEGs encode for transcription factors (TF) which are involved in the control of gene transcription. The early appearance of TF offers a new access to elucidate the link between intentional stimuli and neuroplastic-reactive responses of neurons via alterations of protein synthesis. The expression of IEG encoded TF can be visualized by immunocytochemistry on the protein level (Herdegen et al. 1991a; Hunt et al. 1987; Kovary and Bravo 1991a,b; Morgan et al. 1987) or by in situ hybridization on the mRNA level (Cole et al. 1989; Wisden et al. 1990). |
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| Item Description: | Gesehen am 18.08.2025 |
| Physical Description: | Online Resource |
| ISBN: | 9783642795626 |
| DOI: | 10.1007/978-3-642-79562-6_5 |