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Systemic coordination of whole-body tissue remodeling during local regeneration in sea anemones

The complexity of regeneration extends beyond local wound responses, eliciting systemic processes across the entire organism. However, the functional relevance and coordination of distant molecular processes remain unclear. In the cnidarian Nematostella vectensis, we show that local regeneration tri...

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Main Authors: Cheung, Stephanie (Author) , Bredikhin, Danila (Author) , Gerber, Tobias (Author) , Steenbergen, Petrus J. (Author) , Basu, Soham (Author) , Bailleul, Richard (Author) , Hansen, Pauline (Author) , Paix, Alexandre (Author) , Benton, Matthew A. (Author) , Korswagen, Hendrik C. (Author) , Arendt, Detlev (Author) , Stegle, Oliver (Author) , Ikmi, Aissam (Author)
Format: Article (Journal)
Language:English
Published: 10 March 2025
In: Developmental cell
Year: 2025, Volume: 60, Issue: 5, Pages: 780-793.e7
ISSN:1878-1551
DOI:10.1016/j.devcel.2024.11.001
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.devcel.2024.11.001
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S153458072400666X
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Author Notes:Stephanie Cheung, Danila Bredikhin, Tobias Gerber, Petrus J. Steenbergen, Soham Basu, Richard Bailleul, Pauline Hansen, Alexandre Paix, Matthew A. Benton, Hendrik C. Korswagen, Detlev Arendt, Oliver Stegle, and Aissam Ikmi
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Summary:The complexity of regeneration extends beyond local wound responses, eliciting systemic processes across the entire organism. However, the functional relevance and coordination of distant molecular processes remain unclear. In the cnidarian Nematostella vectensis, we show that local regeneration triggers a systemic homeostatic response, leading to coordinated whole-body remodeling. Leveraging spatial transcriptomics, endogenous protein tagging, and live imaging, we comprehensively dissect this systemic response at the organismal scale. We identify proteolysis as a critical process driven by both local and systemic upregulation of metalloproteases. We show that metalloproteinase expression levels and activity scale with the extent of tissue loss. This proportional response drives long-range tissue and extracellular matrix movement. Our findings demonstrate the adaptive nature of the systematic response in regeneration, enabling the organism to maintain shape homeostasis while coping with a wide range of injuries.
Item Description:Online verfügbar: 29. November 2024, Artikelversion: 10. März 2025
Gesehen am 19.08.2025
Physical Description:Online Resource
ISSN:1878-1551
DOI:10.1016/j.devcel.2024.11.001

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