Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
Rectal carcinomas of previously untreated patients were analyzed for oxygen status using a computerized polarographic needle electrode histograph. Microvessel density and expression of c-jun, vascular endothelial growth factor (VEGF) and several resistance-related proteins (glutathione S-transferase...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 July 1996
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| In: |
International journal of cancer
Year: 1996, Volume: 67, Issue: 1, Pages: 20-23 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291097-0215%2819960703%2967%3A1%3C20%3A%3AAID-IJC5%3E3.0.CO%3B2-1 
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| Author Notes: | Jürgen Mattern, Friedrich Kallinowski, Christian Herfarth, Manfred Volm |
| Summary: | Rectal carcinomas of previously untreated patients were analyzed for oxygen status using a computerized polarographic needle electrode histograph. Microvessel density and expression of c-jun, vascular endothelial growth factor (VEGF) and several resistance-related proteins (glutathione S-transferase-π, GST; thymidylate synthase, TS; metallothioneine, MT) were determined using immunohistochemistry. To examine whether a relationship exists between intratumoral vessel density and tumor oxygenation, microvessel counts were determined in a 400× field using factor-VIII-related antigen and were correlated with the corresponding pO2 values. Linear regression analysis revealed a significant relationship between vessel density and oxygenation status of the tumors. Expression of c-jun, VEGF and resistance-related proteins was correlated with microvessel counts and pO2 values. Significantly lower vessel counts were found in GST- and MT-positive tumors and in tumors with overexpression of c-jun and VEGF than in negative tumors. In addition, significantly lower pO2 values were found in c-jun- and VEGF-positive tumors as well as a tendency for pO2 values to be lower in tumors where MT, GST and TS were expressed. These data show that expression of c-jun, VEGF, and resistance-related proteins is linked with poor vascularization and low oxygenation status in rectal cancer. © 1996 Wiley-Liss, Inc. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 6. Dezember 1998 Gesehen am 20.08.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 |