DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and di...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2024
|
| In: |
Clinical epigenetics
Year: 2024, Volume: 16, Pages: 1-17 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-024-01768-x |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-024-01768-x |
| Author Notes: | Teodor G. Calina, Eilís Perez, Elena Grafenhorst, Jamal Benhamida, Simon Schallenberg, Adrian Popescu, Ines Koch, Tobias Janik, BaoQing Chen, Jana Ihlow, Stephanie Roessler, Benjamin Goeppert, Bruno Sinn, Marcus Bahra, George A. Calin, Eliane T. Taube, Uwe Pelzer, Christopher C. M. Neumann, David Horst, Erik Knutsen, David Capper and Mihnea P. Dragomir |
| Summary: | We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and diagnosis is based on exclusion of other malignancies. Therefore, our focus was to investigate whether the PAAD-iCCA-Classifier can be used to diagnose PAAD metastases from other sites. |
|---|---|
| Item Description: | Online veröffentlicht: 10. November 2024 Gesehen am 20.08.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-024-01768-x |