DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites

We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and di...

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Main Authors: Calina, Teodor G. (Author) , Perez, Eilís (Author) , Grafenhorst, Elena (Author) , Benhamida, Jamal (Author) , Schallenberg, Simon (Author) , Popescu, Adrian (Author) , Koch, Ines (Author) , Janik, Tobias (Author) , Chen, BaoQing (Author) , Ihlow, Jana (Author) , Rössler, Stephanie (Author) , Goeppert, Benjamin (Author) , Sinn, Bruno (Author) , Bahra, Marcus (Author) , Calin, George A. (Author) , Taube, Eliane T. (Author) , Pelzer, Uwe (Author) , Neumann, Christopher C. M. (Author) , Horst, David (Author) , Knutsen, Erik (Author) , Capper, David (Author) , Dragomir, Mihnea P. (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Clinical epigenetics
Year: 2024, Volume: 16, Pages: 1-17
ISSN:1868-7083
DOI:10.1186/s13148-024-01768-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-024-01768-x
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Author Notes:Teodor G. Calina, Eilís Perez, Elena Grafenhorst, Jamal Benhamida, Simon Schallenberg, Adrian Popescu, Ines Koch, Tobias Janik, BaoQing Chen, Jana Ihlow, Stephanie Roessler, Benjamin Goeppert, Bruno Sinn, Marcus Bahra, George A. Calin, Eliane T. Taube, Uwe Pelzer, Christopher C. M. Neumann, David Horst, Erik Knutsen, David Capper and Mihnea P. Dragomir
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Summary:We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and diagnosis is based on exclusion of other malignancies. Therefore, our focus was to investigate whether the PAAD-iCCA-Classifier can be used to diagnose PAAD metastases from other sites.
Item Description:Online veröffentlicht: 10. November 2024
Gesehen am 20.08.2025
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-024-01768-x