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Diabetes mellitus aggravates myocardial inflammation and oxidative stress in aortic stenosis: a mechanistic link to HFpEF features

Patients diagnosed with both aortic stenosis (AS) and diabetes mellitus (DM) encounter a distinctive set of challenges due to the interplay between these two conditions. This study aimed to investigate the effects of DM on the left ventricle in AS patients, specifically focusing on the inflammatory...

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Main Authors: Herwig, Melissa (Author) , Sieme, Marcel (Author) , Kovács, Andrea (Author) , Khan, Muchtiar (Author) , Mügge, Andreas (Author) , Schmidt, Wolfgang E. (Author) , Elci, Ferhat (Author) , Sasidharan, Shan (Author) , Haldenwang, Peter (Author) , Wintrich, Jan (Author) , Sasko, Benjamin (Author) , Akın, Ibrahim (Author) , Domokos, Máthé (Author) , Paneni, Francesco (Author) , El-Battrawy, Ibrahim (Author) , Varga, Zoltán V. (Author) , Saraiva, Francisca (Author) , Leite-Moreira, Adelino F. (Author) , Ferdinandy, Péter (Author) , van Heerebeek, Loek (Author) , Falcão-Pires, Inês (Author) , Hamdani, Nazha (Author)
Format: Article (Journal)
Language:English
Published: 13 May 2025
In: Cardiovascular diabetology
Year: 2025, Volume: 24, Pages: 1-20
ISSN:1475-2840
DOI:10.1186/s12933-025-02748-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12933-025-02748-y
Verlag, kostenfrei, Volltext: https://cardiab.biomedcentral.com/articles/10.1186/s12933-025-02748-y
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Author Notes:Melissa Herwig, Marcel Sieme, Andrea Kovács, Muchtiar Khan, Andreas Mügge, Wolfgang E. Schmidt, Ferhat Elci, Shan Sasidharan, Peter Haldenwang, Jan Wintrich, Benjamin Sasko, Ibrahim Akin, Máthé Domokos, Francesco Paneni, Ibrahim El-Battrawy, Zoltán V. Varga, Francisca Saraiva, Adelino F. Leite-Moreira, Péter Ferdinandy, Loek van Heerebeek, Inês Falcão-Pires and Nazha Hamdani
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Summary:Patients diagnosed with both aortic stenosis (AS) and diabetes mellitus (DM) encounter a distinctive set of challenges due to the interplay between these two conditions. This study aimed to investigate the effects of DM on the left ventricle in AS patients, specifically focusing on the inflammatory response, oxidative stress, and their implications for cardiomyocyte function, titin phosphorylation, and the nitric oxide (NO)-soluble guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signaling pathway.
Item Description:Gesehen am 01.09.2025
Physical Description:Online Resource
ISSN:1475-2840
DOI:10.1186/s12933-025-02748-y

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