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Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification

Breast cancer diagnosed during pregnancy (PrBC) is a rare occurrence but may become more prevalent as women nowadays tend to postpone childbearing until later in life. Further understanding of how pregnancy affects the tumor microenvironment (TME) is essential. We constructed Tissue Microarrays (TMA...

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Main Authors: Galas, Kristin (Author) , Gleitsmann, Moritz (Author) , Rey, Julia (Author) , Solbach, Christine (Author) , Witzel, Isabell (Author) , Karn, Thomas (Author) , Schmatloch, Sabine (Author) , Schem, Christian (Author) , Schneeweiss, Andreas (Author) , Sinn, Bruno (Author) , Fehm, Tanja (Author) , Denkert, Carsten (Author) , Fasching, Peter Andreas (Author) , Litmeyer, Anne-Sophie (Author) , Marmé, Frederik (Author) , Jank, Paul (Author) , Müller, Volkmar (Author) , Seiler, Sabine (Author) , Stickeler, Elmar (Author) , Ortmann, Olaf (Author) , van Mackelenbergh, Marion (Author) , Nekljudova, Valentina (Author) , Holtschmidt, Johannes (Author) , Loibl, Sibylle (Author)
Format: Article (Journal)
Language:English
Published: 14 May 2025
In: npj Breast cancer
Year: 2025, Volume: 11, Issue: 1, Pages: 1-9
ISSN:2374-4677
DOI:10.1038/s41523-025-00758-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41523-025-00758-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41523-025-00758-3
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Author Notes:Kristin Galas, Moritz Gleitsmann, Julia Rey, Christine Solbach, Isabell Witzel, Thomas Karn, Sabine Schmatloch, Christian Schem, Andreas Schneeweis, Bruno Sinn, Tanja Fehm, Carsten Denkert, Peter Fasching, Anne-Sophie Litmeyer, Frederik Marmé, Paul Jank, Volkmar Müller, Sabine Seiler, Elmar Stickeler, Olaf Ortmann, Marion van Mackelenbergh, Valentina Nekljudova, Johannes Holtschmidt & Sibylle Loibl
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Summary:Breast cancer diagnosed during pregnancy (PrBC) is a rare occurrence but may become more prevalent as women nowadays tend to postpone childbearing until later in life. Further understanding of how pregnancy affects the tumor microenvironment (TME) is essential. We constructed Tissue Microarrays (TMA) of tumor specimens from 126 pregnant breast cancer (BC) patients and examined standard BC markers such as ER, PR, Ki67, HER2, tumor infiltrating lymphocytes (TILs), and immunomarkers HLA class I, HLA-G, PD-L1, TIGIT and Nectin-4. Subsequently, we compared our findings with those from a matched non-pregnant cohort of young BC patients. Pregnant BC patients were younger, had significantly higher proliferation rates and a higher expression of Nectin-4. Higher pregnancy related estrogen levels may boost proliferation und Nectin-4 overexpression, promoting BC progression. No further evidence supporting impaired maternal anti-tumor response in BC was observed in this study.
Item Description:Gesehen am 01.09.2025
Physical Description:Online Resource
ISSN:2374-4677
DOI:10.1038/s41523-025-00758-3

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