The IKZF1 N159S mutation is associated with poor outcome and a distinct molecular profile in adult patients with AML

IKZF1 mutations are recurrent alterations in acute myeloid leukaemia (AML), and hotspot point mutation, N159S, has recently been associated with unique gene expression and adverse risk. To better understand the molecular and clinical associations of IKZF1 N159S-mutated AML, we performed a pooled ana...

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Main Authors:	Stasik, Sebastian (Author) , Eckardt, Jan-Niklas (Author) , Röllig, Christoph (Author) , Baldus, Claudia (Author) , Platzbecker, Uwe (Author) , Serve, Hubert (Author) , Müller-Tidow, Carsten (Author) , Schäfer-Eckart, Kerstin (Author) , Kaufmann, Martin (Author) , Krause, Stefan W. (Author) , Sauer, Tim (Author) , Hänel, Mathias (Author) , Neubauer, Andreas (Author) , Ehninger, Gerhard (Author) , Bornhäuser, Martin (Author) , Schetelig, Johannes (Author) , Middeke, Jan M. (Author) , Thiede, Christian (Author)
Format:	Article (Journal)
Language:	English
Published:	May 2025
In:	British journal of haematology Year: 2025, Volume: 206, Issue: 5, Pages: 1373-1379
ISSN:	1365-2141
DOI:	10.1111/bjh.20027
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bjh.20027 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.20027
Author Notes:	Sebastian Stasik, Jan-Niklas Eckardt, Christoph Röllig, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Carsten Müller-Tidow, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan W. Krause, Tim Sauer, Mathias Hänel, Andreas Neubauer, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Christian Thiede, on behalf of the Study Alliance Leukemia (SAL)