Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat
Background - Previous reports demonstrated that radiographic contrast medium, as used in contrast-enhanced computed tomography, increases acinar necrosis and mortality in experimental pancreatitis. The authors studed the possibility that these changes may be related to an additional impai...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1995
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| In: |
Annals of surgery
Year: 1995, Volume: 221, Issue: 3, Pages: 257-264 |
| ISSN: | 1528-1140 |
| DOI: | 10.1097/00000658-199503000-00007 |
| Online Access: | Verlag: https://doi.org/10.1097/00000658-199503000-00007 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/abstract/1995/03000/intravenous_contrast_medium_aggravates_the.7.aspx 
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| Author Notes: | Jan Schmidt, Hubert G. Hotz, Thomas Foitzik, Eduard Ryschich, Heinz J. Buhr, Andrew L. Warshaw, Christian Herfarth, Ernst Klar |
| Summary: | Background - Previous reports demonstrated that radiographic contrast medium, as used in contrast-enhanced computed tomography, increases acinar necrosis and mortality in experimental pancreatitis. The authors studed the possibility that these changes may be related to an additional impairment of pancreatic microcirulation. - Methods - Fifty Wistar rats had acute pancreatitis induced by intraductal glycodeoxycholic acid (10 mmol/L for 10 min) and intravenous cerulein (5 μg/kg/hr for 6 hrs). After rehydration (16 mL/kg), pancreatic capillary perfusion was quantified by means of intravital microscopy at baseline before intravenous infusion of contrast medium (n = 25) or saline (n = 25), and 30 and 60 minutes thereafter. In addition to total capillary flow, capillaries were categorized as high-or low-flow (> or <1.6nL/min). - Results - Pancreatic capillary flow did not change in either high- or low-flow capillaries after saline infusion. However, contrast medium infusion induced a significant decrease of total capillary flow (p < 0.001). Analysis according to the relative flow rate revealed that this was primarity because of a significant additional reduction of perfusion in low-flow capillaries (p < 0.0001). Furthermore, complete capillary stasis was observed in 15.9 ± 3.4% after contrast medium as compared with 3.2 ± 1.2% after saline infusion (p < 0.006). - Conclusion - Radiographic contrast medium aggravates the impairment of pancreatic microcirculation in experimental necrotizing pancreatitis. |
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| Item Description: | Gesehen am 04.09.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1528-1140 |
| DOI: | 10.1097/00000658-199503000-00007 |