Calm in the chaos: Targeting mTOR to reduce glioma-driven neuronal hyperexcitability
Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.1 demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 March 2025
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| In: |
Neuron
Year: 2025, Volume: 113, Issue: 6, Pages: 795-797 |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2025.02.020 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2025.02.020
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| Author Notes: | Matthia A. Karreman and Varun Venkataramani |
| Summary: | Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.1 demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model. |
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| Item Description: | Gesehen am 08.09.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2025.02.020 |