Calm in the chaos: Targeting mTOR to reduce glioma-driven neuronal hyperexcitability
Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.1 demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model.
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 March 2025
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| In: |
Neuron
Year: 2025, Jahrgang: 113, Heft: 6, Pages: 795-797 |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2025.02.020 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2025.02.020
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| Verfasserangaben: | Matthia A. Karreman and Varun Venkataramani |
| Zusammenfassung: | Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al.1 demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model. |
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| Beschreibung: | Gesehen am 08.09.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2025.02.020 |