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Satisfactory outcomes following a second autologous hematopoietic cell transplantation for multiple myeloma in poor stem cell mobilizers: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Autologous hematopoietic cell transplants (auto-HCTs) remain the standard of care for transplant-eligible MM patients. The general practice has been to undergo upfront apheresis following induction to collect sufficient number of CD34+ cells to facilitate two auto-HCTs. However, 5-30% of MM patients...

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Main Authors: Sever, Matjaz (Author) , Drozd-Sokolowska, Joanna (Author) , Gras, Luuk (Author) , Koster, Linda (Author) , Folber, Frantisek (Author) , Mielke, Stephan (Author) , Fenk, Roland (Author) , Basak, Grzegorz W. (Author) , Apperley, Jane F. (Author) , Byrne, Jennifer (Author) , Rambaldi, Alessandro (Author) , Ringhoffer, Mark (Author) , Eder, Matthias (Author) , Trneny, Marek (Author) , Blaise, Didier (Author) , Lenhoff, Stig (Author) , Isaksson, Cecilia (Author) , Passweg, Jakob R. (Author) , Partanen, Anu (Author) , Sakellari, Ioanna (Author) , Schönland, Stefan (Author) , Morris, Curly (Author) , Beksac, Meral (Author) , Raj, Kavita (Author) , Hayden, Patrick J. (Author) , McLornan, Donal (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Bone marrow transplantation
Year: 2025, Volume: 60, Issue: 2, Pages: 211-219
ISSN:1476-5365
DOI:10.1038/s41409-024-02460-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-024-02460-7
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-024-02460-7
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Author Notes:Matjaz Sever, Joanna Drozd-Sokolowska, Luuk Gras, Linda Koster, Frantisek Folber, Stephan Mielke, Roland Fenk, Grzegorz Basak, Jane Apperley, Jennifer Byrne, Alessandro Rambaldi, Mark Ringhoffer, Matthias Eder, Marek Trneny, Didier Blaise, Stig Lenhoff, Cecilia Isaksson, Jakob Passweg, Anu Partanen, Ioanna Sakellari, Stefan Schönland, Curly Morris, Meral Beksac, Kavita Raj, Patrick J. Hayden and Donal P. McLornan
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Summary:Autologous hematopoietic cell transplants (auto-HCTs) remain the standard of care for transplant-eligible MM patients. The general practice has been to undergo upfront apheresis following induction to collect sufficient number of CD34+ cells to facilitate two auto-HCTs. However, 5-30% of MM patients do not initially mobilise a sufficient number of hematopoietic stem cells and are classified as poor mobilizers (PM). We compared the baseline characteristics and outcomes of 61 PMs and 816 non-PM patients who underwent a second auto-HCT and who were enrolled in the non-interventional CALM study (NCT01362972). Only patients who collected CD34+ prior to auto-HCT1 were included. Auto-HCT2 comprised both tandem and salvage transplants. PMs were re-mobilized with plerixafor (n = 24, 39.3%) or non-plerixafor-based regimens (n = 37, 60.7%). There were no significant differences in engraftment, progression-free survival (PFS) or overall survival (OS) after the second auto-HCT between PM and non-PM patients. There was a trend to shorter PFS in PM patients undergoing salvage auto-HCT (median 9.6 vs. 12.9 months; p = 0.08) but no significant difference in OS. The median OS was 41.1 months for PM and 41.2 months for non-PM patients (p = 0.86). These data suggest that salvage mobilization is effective and does not affect overall outcomes after a second auto-HCT.
Item Description:Online veröffentlicht: 12. November 2024
Gesehen am 10.09.2025
Physical Description:Online Resource
ISSN:1476-5365
DOI:10.1038/s41409-024-02460-7

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