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Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is l...

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Main Authors: Saberi, Amin (Author) , Wischnewski, Kevin J. (Author) , Jung, Kyesam (Author) , Lotter, Leon D. (Author) , Schaare, H. Lina (Author) , Banaschewski, Tobias (Author) , Barker, Gareth J. (Author) , Bokde, Arun L. W. (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Grigis, Antoine (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Heinz, Andreas (Author) , Brühl, Rüdiger (Author) , Martinot, Jean-Luc (Author) , Paillère Martinot, Marie-Laure (Author) , Artiges, Eric (Author) , Nees, Frauke (Author) , Papadopoulos Orfanos, Dimitri (Author) , Lemaitre, Herve (Author) , Poustka, Luise (Author) , Hohmann, Sarah (Author) , Holz, Nathalie E. (Author) , Baeuchl, Christian (Author) , Smolka, Michael N. (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Paus, Tomáš (Author) , Dukart, Juergen (Author) , Bernhardt, Boris C. (Author) , Popovych, Oleksandr V. (Author) , Eickhoff, Simon B. (Author) , Valk, Sofie L. (Author)
Format: Article (Journal)
Language:English
Published: Jun 2025
In: Science advances
Year: 2025, Volume: 11, Issue: 23, Pages: 1-21
ISSN:2375-2548
DOI:10.1126/sciadv.adr8164
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adr8164
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.adr8164
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Author Notes:Amin Saberi, Kevin J. Wischnewski, Kyesam Jung, Leon D. Lotter, H. Lina Schaare, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, IMAGEN Consortium, Tomáš Paus, Juergen Dukart, Boris C. Bernhardt, Oleksandr V. Popovych, Simon B. Eickhoff, Sofie L. Valk
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Summary:The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.
Item Description:Online veröffentlicht: 4. Juni 2025
Gesehen am 15.09.2025
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.adr8164

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