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Urine-derived renal tubular epithelial cells resemble functional characteristics of professional antigen-presenting cells and can directly induce BKV-specific T cell responses

Reactivation of the BK virus (BKV) is a critical adverse event after kidney transplantation and can lead to graft loss. BKV-reactive T cell-mediated viral control can be facilitated by reducing immunosuppression. However, the exact mechanism underlying the T cell-mediated BKV clearance in the kidney...

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Main Authors: Roch, Toralf (Author) , Paniskaki, Krystallenia (Author) , Wehler, Patrizia (Author) , Thieme, Constantin J. (Author) , Moradian, Hanieh (Author) , Blazquez-Navarro, Arturo (Author) , Anft, Moritz (Author) , Reinke, Petra (Author) , Westhoff, Timm H. (Author) , Stervbo, Ulrik (Author) , Babel, Nina (Author)
Format: Article (Journal)
Language:English
Published: 04 June 2025
In: Journal of nephrology
Year: 2025, Pages: 1-14
ISSN:1724-6059
DOI:10.1007/s40620-025-02298-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s40620-025-02298-2
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s40620-025-02298-2
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Author Notes:Toralf Roch, Krystallenia Paniskaki, Patrizia Wehler, Constantin J. Thieme, Hanieh Moradian, Arturo Blazquez-Navarro, Moritz Anft, Petra Reinke, Timm H. Westhoff, Ulrik Stervbo, Nina Babel
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Summary:Reactivation of the BK virus (BKV) is a critical adverse event after kidney transplantation and can lead to graft loss. BKV-reactive T cell-mediated viral control can be facilitated by reducing immunosuppression. However, the exact mechanism underlying the T cell-mediated BKV clearance in the kidney transplant is not clear.
Item Description:Gesehen am 15.09.2025
Physical Description:Online Resource
ISSN:1724-6059
DOI:10.1007/s40620-025-02298-2

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