Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal flu...

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Main Authors:	Nicolas, Aude (Author) , Sherva, Richard (Author) , Grenier-Boley, Benjamin (Author) , Kim, Yoontae (Author) , Kikuchi, Masataka (Author) , Timsina, Jigyasha (Author) , Rojas, Itziar de (Author) , Dalmasso, María Carolina (Author) , Zhou, Xiaopu (Author) , Le Guen, Yann (Author) , Arboleda-Bustos, Carlos E. (Author) , Bicalho, Maria Aparecida Camargos (Author) , Guerchet, Maëlenn (Author) , Lee, Sven J. van der (Author) , Goss, Monica (Author) , Castillo, Atahualpa (Author) , Bellenguez, Céline (Author) , Küçükali, Fahri (Author) , Satizabal, Claudia L. (Author) , Fongang, Bernard (Author) , Yang, Qiong (Author) , Peters, Oliver Hubertus (Author) , Schneider, Anja (Author) , Dichgans, Martin (Author) , Rujescu, Dan (Author) , Scherbaum, Norbert (Author) , Deckert, Jürgen (Author) , Riedel-Heller, Steffi Gerlinde (Author) , Hausner, Lucrezia (Author) , Molina-Porcel, Laura (Author) , Düzel, Emrah (Author) , Grimmer, Timo (Author) , Wiltfang, Jens (Author) , Heilmann, Stefanie (Author) , Moebus, Susanne (Author) , Tegos, Thomas (Author) , Scarmeas, Nikolaos (Author) , Dols-Icardo, Oriol (Author) , Moreno, Fermin (Author) , Pérez-Tur, Jordi (Author) , Bullido, María J. (Author) , Pastor, Pau (Author) , Sánchez-Valle, Raquel (Author) , Álvarez, Victoria (Author) , Cao, Han (Author) , Ip, Nancy Y. (Author) , Fu, Amy K. Y. (Author) , Ip, Fanny C. F. (Author) , Olivar, Natividad (Author) , Muchnik, Carolina (Author) , Cuesta, Carolina (Author) , Campanelli, Lorenzo (Author) , Solis, Patricia (Author) , Politis, Daniel Gustavo (Author) , Kochen, Silvia (Author) , Brusco, Luis Ignacio (Author) , Boada, Mercè (Author) , García-González, Pablo (Author) , Puerta, Raquel (Author) , Mir, Pablo (Author) , Real, Luis M. (Author) , Piñol-Ripoll, Gerard (Author) , García-Alberca, Jose María (Author) , Royo, Jose Luís (Author) , Rodriguez-Rodriguez, Eloy (Author) , Soininen, Hilkka (Author) , Heikkinen, Sami (Author) , Mendonça, Alexandre de (Author) , Mehrabian, Shima (Author) , Traykov, Latchezar (Author) , Hort, Jakub (Author) , Vyhnalek, Martin (Author) , Rasmussen, Katrine Laura (Author) , Thomassen, Jesper Qvist (Author) , Pijnenburg, Yolande A. L. (Author) , Holstege, Henne (Author) , Swieten, John C. van (Author) , Seelaar, Harro (Author) , Claassen, Jurgen A. H. R. (Author) , Jansen, Willemijn J. (Author) , Ramakers, Inez (Author) , Verhey, Frans (Author) , Lugt, Aad van der (Author) , Scheltens, Philip (Author) , Ortega-Rojas, Jenny (Author) , Mera, Ana Gabriela Concha (Author) , Mahecha, Maria F. (Author) , Pardo, Rodrigo (Author) , Arboleda, Gonzalo (Author) , Bahrami, Shahram (Author) , Fominykh, Vera (Author) , Selbæk, Geir (Author) , Graff, Caroline (Author) , Papenberg, Goran (Author) , Giedraitis, Vilmantas (Author) , Boland, Anne (Author) , Deleuze, Jean-François (Author) , Marco, Luiz Armando de (Author) , Moraes, Edgar Nunes de (Author) , Mattos Viana, Bernardo de (Author) , Cintra, Marco Túlio Gualberto (Author) , Juarez-Cedillo, Teresa (Author) , Griswold, Anthony J. (Author) , Forund, Tatiana (Author) , Haines, Jonathan L. (Author) , Farrer, Lindsay (Author) , DeStefano, Anita (Author) , Wijsman, Ellen (Author) , Mayeux, Richard (Author) , Pericak-Vance, Margaret Ann (Author) , Kunkle, Brian W. (Author) , Goate, Alison (Author) , Schellenberg, Gerard D. (Author) , Vardarajan, Badri (Author) , Wang, Li-San (Author) , Leung, Yuk Yee (Author) , Dalgard, Clifton L. (Author) , Nicolas, Gaël (Author) , Wallon, David (Author) , Dufouil, Carole (Author) , Pasquier, Florence (Author) , Hanon, Olivier (Author) , Debette, Stéphanie (Author) , Grünblatt, Edna (Author) , Popp, Julius Daniel (Author) , Angel, Bárbara (Author) , Gloger, Sergio (Author) , Chacon, Maria Victoria (Author) , Aranguiz, Rafael (Author) , Orellana, Paulina (Author) , Slachevsky, Andrea (Author) , Gonzalez-Billault, Christian (Author) , Albala, Cecilia (Author) , Fuentes, Patricio (Author) , Sachdev, Perminder S., Neuropsychiater (Author) , Mather, Karen A. (Author) , Hauger, Richard L. (Author) , Merritt, Victoria (Author) , Panizzon, Matthew (Author) , Zhang, Rui (Author) , Gaziano, J. Michael (Author) , Ghidoni, Roberta (Author) , Galimberti, Daniela (Author) , Arosio, Beatrice (Author) , Mecocci, Patrizia (Author) , Solfrizzi, Vincenzo (Author) , Parnetti, Lucilla (Author) , Squassina, Alessio (Author) , Tremolizzo, Lucio (Author) , Borroni, Barbara (Author) , Nacmias, Benedetta (Author) , Caffarra, Paolo (Author) , Seripa, Davide (Author) , Rainero, Innocenzo (Author) , Daniele, Antonio (Author) , Piras, Fabrizio (Author) , Leonard, Hampton L. (Author) , Yokoyama, Jenifer S. (Author) , Nalls, Mike A. (Author) , Miyashita, Akinori (Author) , Hara, Norikazu (Author) , Ozaki, Kouichi (Author) , Niida, Shumpei (Author) , Williams, Julie (Author) , Masullo, Carlo (Author) , Amouyel, Philippe (Author) , Preux, Pierre-Marie (Author) , Mbelesso, Pascal (Author) , Bandzouzi, Bébène (Author) , Saykin, Andy (Author) , Jessen, Frank (Author) , Kehoe, Patrick G. (Author) , Duijn, Cornelia van (Author) , Salem, Nesrine Ben (Author) , Frikke-Schmidt, Ruth (Author) , Cherni, Lotfi (Author) , Greicius, Michael D. (Author) , Tsolaki, Magda (Author) , Sánchez-Juan, Pascual (Author) , Silva, Marco Aurélio Romano (Author) , Porter, Tenielle (Author) , Laws, Simon M. (Author) , Sleegers, Kristel (Author) , Ingelsson, Martin (Author) , Dartigues, Jean-François (Author) , Seshadri, Sudha (Author) , Rossi, Giacomina (Author) , Morelli, Laura (Author) , Hiltunen, Mikko (Author) , Sims, Rebecca (Author) , Flier, Wiesje Maria van der (Author) , Andreassen, Ole A. (Author) , Arboleda, Humberto (Author) , Cruchaga, Carlos (Author) , Escott-Price, Valentina (Author) , Ruiz, Agustín (Author) , Lee, Kun Ho (Author) , Ikeuchi, Takeshi (Author) , Ramírez, Alfredo (Author) , Gim, Jungsoo (Author) , Logue, Mark (Author) , Lambert, Jean-Charles (Author) , Frölich, Lutz (Author)
Format:	Article (Journal)
Language:	English
Published:	July 2025
In:	Nature genetics Year: 2025, Volume: 57, Issue: 7, Pages: 1598-1610
ISSN:	1546-1718
DOI:	10.1038/s41588-025-02227-w
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41588-025-02227-w Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41588-025-02227-w
Author Notes:	Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Jigyasha Timsina, Itziar de Rojas, María Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E. Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia L. Satizabal, Bernard Fongang, Qiong Yang, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Lutz Froelich [und viele weitere]