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Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal flu...

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Bibliographische Detailangaben
Hauptverfasser: Nicolas, Aude (VerfasserIn) , Sherva, Richard (VerfasserIn) , Grenier-Boley, Benjamin (VerfasserIn) , Kim, Yoontae (VerfasserIn) , Kikuchi, Masataka (VerfasserIn) , Timsina, Jigyasha (VerfasserIn) , Rojas, Itziar de (VerfasserIn) , Dalmasso, María Carolina (VerfasserIn) , Zhou, Xiaopu (VerfasserIn) , Le Guen, Yann (VerfasserIn) , Arboleda-Bustos, Carlos E. (VerfasserIn) , Bicalho, Maria Aparecida Camargos (VerfasserIn) , Guerchet, Maëlenn (VerfasserIn) , Lee, Sven J. van der (VerfasserIn) , Goss, Monica (VerfasserIn) , Castillo, Atahualpa (VerfasserIn) , Bellenguez, Céline (VerfasserIn) , Küçükali, Fahri (VerfasserIn) , Satizabal, Claudia L. (VerfasserIn) , Fongang, Bernard (VerfasserIn) , Yang, Qiong (VerfasserIn) , Peters, Oliver Hubertus (VerfasserIn) , Schneider, Anja (VerfasserIn) , Dichgans, Martin (VerfasserIn) , Rujescu, Dan (VerfasserIn) , Scherbaum, Norbert (VerfasserIn) , Deckert, Jürgen (VerfasserIn) , Riedel-Heller, Steffi Gerlinde (VerfasserIn) , Hausner, Lucrezia (VerfasserIn) , Molina-Porcel, Laura (VerfasserIn) , Düzel, Emrah (VerfasserIn) , Grimmer, Timo (VerfasserIn) , Wiltfang, Jens (VerfasserIn) , Heilmann, Stefanie (VerfasserIn) , Moebus, Susanne (VerfasserIn) , Tegos, Thomas (VerfasserIn) , Scarmeas, Nikolaos (VerfasserIn) , Dols-Icardo, Oriol (VerfasserIn) , Moreno, Fermin (VerfasserIn) , Pérez-Tur, Jordi (VerfasserIn) , Bullido, María J. (VerfasserIn) , Pastor, Pau (VerfasserIn) , Sánchez-Valle, Raquel (VerfasserIn) , Álvarez, Victoria (VerfasserIn) , Cao, Han (VerfasserIn) , Ip, Nancy Y. (VerfasserIn) , Fu, Amy K. Y. (VerfasserIn) , Ip, Fanny C. F. (VerfasserIn) , Olivar, Natividad (VerfasserIn) , Muchnik, Carolina (VerfasserIn) , Cuesta, Carolina (VerfasserIn) , Campanelli, Lorenzo (VerfasserIn) , Solis, Patricia (VerfasserIn) , Politis, Daniel Gustavo (VerfasserIn) , Kochen, Silvia (VerfasserIn) , Brusco, Luis Ignacio (VerfasserIn) , Boada, Mercè (VerfasserIn) , García-González, Pablo (VerfasserIn) , Puerta, Raquel (VerfasserIn) , Mir, Pablo (VerfasserIn) , Real, Luis M. (VerfasserIn) , Piñol-Ripoll, Gerard (VerfasserIn) , García-Alberca, Jose María (VerfasserIn) , Royo, Jose Luís (VerfasserIn) , Rodriguez-Rodriguez, Eloy (VerfasserIn) , Soininen, Hilkka (VerfasserIn) , Heikkinen, Sami (VerfasserIn) , Mendonça, Alexandre de (VerfasserIn) , Mehrabian, Shima (VerfasserIn) , Traykov, Latchezar (VerfasserIn) , Hort, Jakub (VerfasserIn) , Vyhnalek, Martin (VerfasserIn) , Rasmussen, Katrine Laura (VerfasserIn) , Thomassen, Jesper Qvist (VerfasserIn) , Pijnenburg, Yolande A. L. (VerfasserIn) , Holstege, Henne (VerfasserIn) , Swieten, John C. van (VerfasserIn) , Seelaar, Harro (VerfasserIn) , Claassen, Jurgen A. H. R. (VerfasserIn) , Jansen, Willemijn J. (VerfasserIn) , Ramakers, Inez (VerfasserIn) , Verhey, Frans (VerfasserIn) , Lugt, Aad van der (VerfasserIn) , Scheltens, Philip (VerfasserIn) , Ortega-Rojas, Jenny (VerfasserIn) , Mera, Ana Gabriela Concha (VerfasserIn) , Mahecha, Maria F. (VerfasserIn) , Pardo, Rodrigo (VerfasserIn) , Arboleda, Gonzalo (VerfasserIn) , Bahrami, Shahram (VerfasserIn) , Fominykh, Vera (VerfasserIn) , Selbæk, Geir (VerfasserIn) , Graff, Caroline (VerfasserIn) , Papenberg, Goran (VerfasserIn) , Giedraitis, Vilmantas (VerfasserIn) , Boland, Anne (VerfasserIn) , Deleuze, Jean-François (VerfasserIn) , Marco, Luiz Armando de (VerfasserIn) , Moraes, Edgar Nunes de (VerfasserIn) , Mattos Viana, Bernardo de (VerfasserIn) , Cintra, Marco Túlio Gualberto (VerfasserIn) , Juarez-Cedillo, Teresa (VerfasserIn) , Griswold, Anthony J. (VerfasserIn) , Forund, Tatiana (VerfasserIn) , Haines, Jonathan L. (VerfasserIn) , Farrer, Lindsay (VerfasserIn) , DeStefano, Anita (VerfasserIn) , Wijsman, Ellen (VerfasserIn) , Mayeux, Richard (VerfasserIn) , Pericak-Vance, Margaret Ann (VerfasserIn) , Kunkle, Brian W. (VerfasserIn) , Goate, Alison (VerfasserIn) , Schellenberg, Gerard D. (VerfasserIn) , Vardarajan, Badri (VerfasserIn) , Wang, Li-San (VerfasserIn) , Leung, Yuk Yee (VerfasserIn) , Dalgard, Clifton L. (VerfasserIn) , Nicolas, Gaël (VerfasserIn) , Wallon, David (VerfasserIn) , Dufouil, Carole (VerfasserIn) , Pasquier, Florence (VerfasserIn) , Hanon, Olivier (VerfasserIn) , Debette, Stéphanie (VerfasserIn) , Grünblatt, Edna (VerfasserIn) , Popp, Julius Daniel (VerfasserIn) , Angel, Bárbara (VerfasserIn) , Gloger, Sergio (VerfasserIn) , Chacon, Maria Victoria (VerfasserIn) , Aranguiz, Rafael (VerfasserIn) , Orellana, Paulina (VerfasserIn) , Slachevsky, Andrea (VerfasserIn) , Gonzalez-Billault, Christian (VerfasserIn) , Albala, Cecilia (VerfasserIn) , Fuentes, Patricio (VerfasserIn) , Sachdev, Perminder S., Neuropsychiater (VerfasserIn) , Mather, Karen A. (VerfasserIn) , Hauger, Richard L. (VerfasserIn) , Merritt, Victoria (VerfasserIn) , Panizzon, Matthew (VerfasserIn) , Zhang, Rui (VerfasserIn) , Gaziano, J. Michael (VerfasserIn) , Ghidoni, Roberta (VerfasserIn) , Galimberti, Daniela (VerfasserIn) , Arosio, Beatrice (VerfasserIn) , Mecocci, Patrizia (VerfasserIn) , Solfrizzi, Vincenzo (VerfasserIn) , Parnetti, Lucilla (VerfasserIn) , Squassina, Alessio (VerfasserIn) , Tremolizzo, Lucio (VerfasserIn) , Borroni, Barbara (VerfasserIn) , Nacmias, Benedetta (VerfasserIn) , Caffarra, Paolo (VerfasserIn) , Seripa, Davide (VerfasserIn) , Rainero, Innocenzo (VerfasserIn) , Daniele, Antonio (VerfasserIn) , Piras, Fabrizio (VerfasserIn) , Leonard, Hampton L. (VerfasserIn) , Yokoyama, Jenifer S. (VerfasserIn) , Nalls, Mike A. (VerfasserIn) , Miyashita, Akinori (VerfasserIn) , Hara, Norikazu (VerfasserIn) , Ozaki, Kouichi (VerfasserIn) , Niida, Shumpei (VerfasserIn) , Williams, Julie (VerfasserIn) , Masullo, Carlo (VerfasserIn) , Amouyel, Philippe (VerfasserIn) , Preux, Pierre-Marie (VerfasserIn) , Mbelesso, Pascal (VerfasserIn) , Bandzouzi, Bébène (VerfasserIn) , Saykin, Andy (VerfasserIn) , Jessen, Frank (VerfasserIn) , Kehoe, Patrick G. (VerfasserIn) , Duijn, Cornelia van (VerfasserIn) , Salem, Nesrine Ben (VerfasserIn) , Frikke-Schmidt, Ruth (VerfasserIn) , Cherni, Lotfi (VerfasserIn) , Greicius, Michael D. (VerfasserIn) , Tsolaki, Magda (VerfasserIn) , Sánchez-Juan, Pascual (VerfasserIn) , Silva, Marco Aurélio Romano (VerfasserIn) , Porter, Tenielle (VerfasserIn) , Laws, Simon M. (VerfasserIn) , Sleegers, Kristel (VerfasserIn) , Ingelsson, Martin (VerfasserIn) , Dartigues, Jean-François (VerfasserIn) , Seshadri, Sudha (VerfasserIn) , Rossi, Giacomina (VerfasserIn) , Morelli, Laura (VerfasserIn) , Hiltunen, Mikko (VerfasserIn) , Sims, Rebecca (VerfasserIn) , Flier, Wiesje Maria van der (VerfasserIn) , Andreassen, Ole A. (VerfasserIn) , Arboleda, Humberto (VerfasserIn) , Cruchaga, Carlos (VerfasserIn) , Escott-Price, Valentina (VerfasserIn) , Ruiz, Agustín (VerfasserIn) , Lee, Kun Ho (VerfasserIn) , Ikeuchi, Takeshi (VerfasserIn) , Ramírez, Alfredo (VerfasserIn) , Gim, Jungsoo (VerfasserIn) , Logue, Mark (VerfasserIn) , Lambert, Jean-Charles (VerfasserIn) , Frölich, Lutz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: July 2025
In: Nature genetics
Year: 2025, Jahrgang: 57, Heft: 7, Pages: 1598-1610
ISSN:1546-1718
DOI:10.1038/s41588-025-02227-w
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41588-025-02227-w
Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41588-025-02227-w
Volltext
Verfasserangaben:Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Jigyasha Timsina, Itziar de Rojas, María Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E. Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia L. Satizabal, Bernard Fongang, Qiong Yang, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Lutz Froelich [und viele weitere]

MARC

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100 1 |a Nicolas, Aude  |e VerfasserIn  |0 (DE-588)123554995X  |0 (DE-627)1760573906  |4 aut 
245 1 0 |a Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations  |c Aude Nicolas, Richard Sherva, Benjamin Grenier-Boley, Yoontae Kim, Masataka Kikuchi, Jigyasha Timsina, Itziar de Rojas, María Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E. Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia L. Satizabal, Bernard Fongang, Qiong Yang, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Lutz Froelich [und viele weitere] 
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520 |a A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD. 
650 4 |a Alzheimer's disease 
650 4 |a Genome-wide association studies 
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SRT |a NICOLASAUDTRANSFERAB2025 

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