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Intradermal advanced glycation end-products relate to reduced sciatic nerve structural integrity in type 2 diabetes

Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed to...

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Main Authors: Mooshage, Christoph (Author) , Tsilingiris, Dimitrios (Author) , Schimpfle, Lukas (Author) , Fleming, Thomas (Author) , Herzig, Stephan (Author) , Szendrödi, Julia (Author) , Heiland, Sabine (Author) , Bendszus, Martin (Author) , Kopf, Stefan (Author) , Kurz, Felix T. (Author) , Jende, Johann (Author) , Kender, Zoltán (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2025
In: Clinical neuroradiology
Year: 2025, Volume: 35, Issue: 2, Pages: 385-394
ISSN:1869-1447
DOI:10.1007/s00062-024-01493-1
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00062-024-01493-1
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Author Notes:Christoph M. Mooshage, Dimitrios Tsilingiris, Lukas Schimpfle, Thomas Fleming, Stephan Herzig, Julia Szendroedi, Sabine Heiland, Martin Bendszus, Stefan Kopf, Felix Kurz, Johann Jende, Zoltan Kender
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Summary:Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed to evaluate the correlation between skin auto-fluorescence (sAF), an indicator of dermal advanced glycation end-product (AGE) accumulations, cardiovascular risk, and changes in peripheral nerve integrity.
Item Description:Gesehen am 17.09.2025
Physical Description:Online Resource
ISSN:1869-1447
DOI:10.1007/s00062-024-01493-1

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