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Nanocarriers-based therapeutic strategy for drug-resistant epilepsy: a systematic review

Background - Nanocarriers have been proposed as a solution for drug-resistant epilepsy. - Methods - A systematic review of animal and in vitro studies was conducted to evaluate the efficacy, toxicity, and biological properties of nanocarriers. Searches were performed in PubMed/Medline and Scopus fro...

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Main Authors: Díaz-Peregrino, Roberto (Author) , San Juan Orta, Daniel (Author) , Patiño-Ramirez, Carlos (Author) , Sandoval-Luna, Lenin V. (Author) , Arritola-Uriarte, Aleida (Author)
Format: Article (Journal)
Language:English
Published: 5 January 2025
In: International journal of pharmaceutics
Year: 2025, Volume: 668, Pages: 1-12
ISSN:1873-3476
DOI:10.1016/j.ijpharm.2024.124986
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ijpharm.2024.124986
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0378517324012201
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Author Notes:Roberto Diaz-Peregrino, Daniel San-Juan, Carlos Patiño-Ramirez, Lenin V. Sandoval-Luna, Aleida Arritola-Uriarte
Description
Summary:Background - Nanocarriers have been proposed as a solution for drug-resistant epilepsy. - Methods - A systematic review of animal and in vitro studies was conducted to evaluate the efficacy, toxicity, and biological properties of nanocarriers. Searches were performed in PubMed/Medline and Scopus from March 2023 to March 2024. - Results - Eighteen studies were identified: 2 in vitro, 9 in vivo, and 7 combined. While epilepsy models and seizure control assessments were consistent, there was variability in evaluating the potential toxicity of nanocarriers. Only one study did not show a reduction in brain inflammation, seizures, and cell loss. Nanocarrier toxicity was evaluated just in six studies, all of which indicated low toxicity both in vitro and in vivo. - Conclusions - Nanocarriers with antiseizure drugs manage seizures, inflammation, oxidative stress, and behavior impairment in drug-resistant epilepsy. Furthermore, nanocarriers are a safe option for delivering antiseizure drugs, though more research is needed to confirm these findings.
Item Description:Online veröffentlicht: 22. November 2024, Artikelversion: 25. November 2024
Gesehen am 17.09.2025
Physical Description:Online Resource
ISSN:1873-3476
DOI:10.1016/j.ijpharm.2024.124986

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