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Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants

Background - Late-onset Alzheimer's disease is consistently associated with alterations in the default-mode network (DMN)—a large-scale brain network associated with self-related processing and memory. However, the functional organization of DMN is far less clear in young-onset Alzheimer's...

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Main Authors: Sacu, Seda (Author) , Slattery, Catherine F (Author) , Friston, Karl J (Author) , Paterson, Ross W (Author) , Foulkes, Alexander JM (Author) , Yong, Keir (Author) , Crutch, Sebastian (Author) , Schott, Jonathan M (Author) , Razi, Adeel (Author)
Format: Article (Journal)
Language:English
Published: July 2025
In: Journal of Alzheimer's disease
Year: 2025, Volume: 106, Issue: 2, Pages: 653-667
ISSN:1875-8908
DOI:10.1177/13872877251344325
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1177/13872877251344325
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Author Notes:Seda Sacu, Catherine F Slattery, Karl J Friston, Ross W Paterson, Alexander JM Foulkes, Keir Yong, Sebastian Crutch, Jonathan M Schott and Adeel Razi
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Summary:Background - Late-onset Alzheimer's disease is consistently associated with alterations in the default-mode network (DMN)—a large-scale brain network associated with self-related processing and memory. However, the functional organization of DMN is far less clear in young-onset Alzheimer's disease (YOAD). - Objective - The current study aimed to identify effective connectivity changes in the core DMN nodes between YOAD variants and healthy controls. - Methods - We assessed resting-state DMN effective connectivity in two common YOAD variants (i.e., amnestic variant (n = 26) and posterior cortical atrophy (n = 13) and healthy participants (n = 24) to identify disease- and variant-specific connectivity differences using spectral dynamic causal modelling. - Results - Patients with the amnestic variant showed increased connectivity from prefrontal cortex to posterior DMN nodes relative to healthy controls, whereas patients with posterior cortical atrophy exhibited decreased posterior DMN connectivity. Right hippocampus connectivity differentiated the two patient groups. Furthermore, disease-related connectivity alterations were also predictive of group membership and cognitive performance. - Conclusions - These findings suggest that resting-state DMN effective connectivity provides a new understanding of neural mechanisms underlying the disease pathology and cognition in YOAD.
Item Description:Erstmals veröffentlicht: 1. Juli 2025
Gesehen am 16.09.2025
Physical Description:Online Resource
ISSN:1875-8908
DOI:10.1177/13872877251344325

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