Targeting autophagy to treat neointimal hyperplasia in vascular disease
This editorial refers to ‘Novel roles of Nrf3-Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia’ by Q. Chen et al., https://doi.org/10.1093/cvr/cvaf084.Neointimal hyperplasia is a maladaptive response to vascular injury characterized by a pathologic thickening of the...
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| Main Authors: | , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
July 2025
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| In: |
Cardiovascular research
Year: 2025, Volume: 121, Issue: 8, Pages: 1149-1151 |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvaf104 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/cvr/cvaf104
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| Author Notes: | Runan Yan, Simon Tual-Chalot, and Konstantinos Stellos |
| Summary: | This editorial refers to ‘Novel roles of Nrf3-Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia’ by Q. Chen et al., https://doi.org/10.1093/cvr/cvaf084.Neointimal hyperplasia is a maladaptive response to vascular injury characterized by a pathologic thickening of the intimal layer of blood vessels. It is caused by multiple factors, including mechanical damage from interventional procedures, inflammatory responses within the vascular wall, haemodynamic changes, diabetes mellitus, and dyslipidemia.1 Neointimal hyperplasia appears in a variety of vascular diseases including atherosclerosis, post-stent restenosis, vascular graft disease, transplant vasculopathy, arteriovenous fistula disease, hypertensive vascular disease or vasculitis. In all these conditions, neointimal hyperplasia contributes to luminal narrowing, which impairs blood flow and can lead to ischaemic complications in the affected tissue or organ.1 |
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| Item Description: | Online veröffentlicht: 20. Juni 2025 Gesehen am 22.09.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvaf104 |