Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version
Background: Cerebellar disease may result in Cerebellar Cognitive Affective Syndrome (CCAS). The CCAS-Scale, designed to screen for CCAS, has been validated in English Hoche (Brain 141:248–270, 2018) and adapted to other languages. Methods: Here, the German CCAS-Scale Thieme (Neurol Res Pract 2:39,...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 April 2025
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| In: |
Journal of neurology
Year: 2025, Jahrgang: 272, Heft: 5, Pages: 1-18 |
| ISSN: | 1432-1459 |
| DOI: | 10.1007/s00415-025-13083-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00415-025-13083-3
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| Verfasserangaben: | Andreas Thieme, Kerstin Rubarth, Raquel van der Veen, Johanna Müller, Jennifer Faber, Miriam Barkhoff, Martina Minnerop, Saskia Elben, Dana Huvermann, Friedrich Erdlenbruch, Adam M. Berlijn, Patricia Sulzer, Kathrin Reetz, Imis Dogan, Heike Jacobi, Julia-Elisabeth Aktories, Giorgi Batsikadze, Qi Liu, Benedikt Frank, Martin Köhrmann, Elke Wondzinski, Mario Siebler, Jürgen Konczak, Matthis Synofzik, Thomas Klockgether, Frank Konietschke, Sandra Röske, Dagmar Timmann |
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| 245 | 1 | 0 | |a Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version |c Andreas Thieme, Kerstin Rubarth, Raquel van der Veen, Johanna Müller, Jennifer Faber, Miriam Barkhoff, Martina Minnerop, Saskia Elben, Dana Huvermann, Friedrich Erdlenbruch, Adam M. Berlijn, Patricia Sulzer, Kathrin Reetz, Imis Dogan, Heike Jacobi, Julia-Elisabeth Aktories, Giorgi Batsikadze, Qi Liu, Benedikt Frank, Martin Köhrmann, Elke Wondzinski, Mario Siebler, Jürgen Konczak, Matthis Synofzik, Thomas Klockgether, Frank Konietschke, Sandra Röske, Dagmar Timmann |
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| 520 | |a Background: Cerebellar disease may result in Cerebellar Cognitive Affective Syndrome (CCAS). The CCAS-Scale, designed to screen for CCAS, has been validated in English Hoche (Brain 141:248–270, 2018) and adapted to other languages. Methods: Here, the German CCAS-Scale Thieme (Neurol Res Pract 2:39, 2020) was validated in 209 patients with cerebellar disorders and 232 healthy controls. Correction formulas for the outcome parameters [failed test items (range: 1–10) and sum raw score (range: 0–120)] were developed, controlling for age, education, and sex effects. Diagnostic accuracy and reliability were assessed. Results: Correction formulas improved selectivity in controls, reducing false positives (failed items: 40%; sum score: 13% vs. original method Hoche (Brain 141:248–270, 2018): 67%), while maintaining moderate sensitivity (failed items: 69%; sum score: 48% vs. original method Hoche (Brain 141:248–270, 2018): 87%). Word fluency tests differentiated best between patients and controls, while other items did not. Internal consistency (α = 0.71) was acceptable. Removal of word fluency tests worsened it. Retest and interrater reliability were high [intraclass correlation coefficients (ICC): 0.77–0.95]. However, these ICCs yielded a large minimal detectable change (MDC; 2.2–2.4 failed items, 9.5–11.4 raw score points) in patients, limiting the use of the CCAS-Scale in follow-up examinations. Conclusion: The correction formulas improved diagnostic accuracy of the CCAS-Scale, particularly for the sum raw score. Therefore, we recommend using the corrected sum raw score for evaluation instead of the uncorrected number of failed items, proposed originally Hoche (Brain 141:248–270, 2018). Some test items, however, did not differentiate well between patients and controls and MDCs were large, highlighting the need for refined CCAS assessment instruments as progression or treatment outcomes. | ||
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