Density and entropy of immune cells within the tumor microenvironment of primary tumors and matched brain metastases

Tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) have increasingly been reported to impact the brain metastatic process of solid tumors. However, data on intra-individual differences between primary tumor and brain metastasis (BM), as well as their correlation with clini...

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Main Authors: Kleinberger, Markus (Author) , Cifci, Didem (Author) , Paiato, Christina (Author) , Tomasich, Erwin (Author) , Mair, Maximilian (Author) , Steindl, Ariane (Author) , Spiró, Zoltán Péter (Author) , Carrero, Zunamys I. (Author) , Berchtold, Luzia (Author) , Hainfellner, Johannes A. (Author) , Müllauer, Leonhard (Author) , Heller, Gerwin (Author) , Preusser, Matthias (Author) , Kather, Jakob Nikolas (Author) , Bergmeister-Berghoff, Anna Sophie (Author)
Format: Article (Journal)
Language:English
Published: Februar 2025
In: Acta Neuropathologica Communications
Year: 2025, Volume: 13, Issue: 1, Pages: 1-12
ISSN:2051-5960
DOI:10.1186/s40478-025-01939-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40478-025-01939-8
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Author Notes:Markus Kleinberger, Didem Çifçi, Christina Paiato, Erwin Tomasich, Maximilian J. Mair, Ariane Steindl, Zoltán Spiró, Zunamys I. Carrero, Luzia Berchtold, Johannes Hainfellner, Leonhard Müllauer, Gerwin Heller, Matthias Preusser, Jakob Niklas Kather and Anna Sophie Berghoff
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Summary:Tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) have increasingly been reported to impact the brain metastatic process of solid tumors. However, data on intra-individual differences between primary tumor and brain metastasis (BM), as well as their correlation with clinical outcome parameters, is scarce.
Item Description:Online veröffentlicht am 19. Februar 2025
Gesehen am 13.10.2025
Physical Description:Online Resource
ISSN:2051-5960
DOI:10.1186/s40478-025-01939-8