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Clinical outcomes of pediatric kidney replacement therapy after childhood cancer: an ESPN/ERA registry study

Cancer and its treatment may lead to kidney injury and the need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a history of malignancy from the European Society for Paediatric Nephrology/European Renal Association Registry. Of these, 197 had cancer as a primary c...

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Main Authors: Kaijansinkko, Henna (Author) , Bonthuis, Marjolein (Author) , Jahnukainen, Kirsi (Author) , Harambat, Jerome (Author) , Vidal, Enrico (Author) , Bakkaloglu, Sevcan A. (Author) , Inward, Carol (Author) , Sinha, Manish D. (Author) , Roperto, Rosa M. (Author) , Kuehni, Claudia E. (Author) , Biró, Erika (Author) , Kwon, Theresa (Author) , Mota, Conceição (Author) , Adams, Brigitte (Author) , Szczepańska, Maria (Author) , Bieniaś, Beata (Author) , Höcker, Britta (Author) , Fomina, Svitlana (Author) , Gjerstad, Ann Christin (Author) , Vondrak, Karel (Author) , Alpay, Harika (Author) , Plumb, Lucy A. (Author) , Hommel, Kristine (Author) , Molchanova, Maria S. (Author) , Hubmann, Holger (Author) , Alonso-Melgar, Angel (Author) , Jager, Kitty J. (Author) , Jahnukainen, Timo (Author)
Format: Article (Journal)
Language:English
Published: April 2025
In: American journal of transplantation
Year: 2025, Volume: 25, Issue: 4, Pages: 767-779
ISSN:1600-6143
DOI:10.1016/j.ajt.2024.11.002
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ajt.2024.11.002
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1600613524006865
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Author Notes:Henna Kaijansinkko, Marjolein Bonthuis, Kirsi Jahnukainen, Jerome Harambat, Enrico Vidal, Sevcan A. Bakkaloglu, Carol Inward, Manish D. Sinha, Rosa M. Roperto, Claudia E. Kuehni, Erika Biró, Theresa Kwon, Conceição Mota, Brigitte Adams, Maria Szczepańska, Beata Bieniaś, Britta Höcker, Svitlana Fomina, Ann Christin Gjerstad, Karel Vondrak, Harika Alpay, Lucy A. Plumb, Kristine Hommel, Maria S. Molchanova, Holger Hubmann, Angel Alonso-Melgar, Kitty J. Jager, Timo Jahnukainen
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Summary:Cancer and its treatment may lead to kidney injury and the need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a history of malignancy from the European Society for Paediatric Nephrology/European Renal Association Registry. Of these, 197 had cancer as a primary cause of KRT (group 1) and 90 had a malignancy diagnosis before KRT (group 2). Two matched controls without malignancy were randomly selected for each patient. Data were complemented with a questionnaire. Median time to kidney transplantation (KT) from KRT initiation was 2.4 (IQR: 1.5-4.7), 1.5 (IQR: 0.4-3.3), 3.6 (IQR: 1.3 to Q3 not reached), and 1.1 (IQR: 0.3-3.6) years for group 1, their controls, group 2, and their controls, respectively. Overall 10-year mortality for those on KRT was higher among cancer patients vs controls in group 1: 16% vs 9% (adjusted hazard ratio 2.02, 95% CI: 1.21-3.37) and in group 2: 23% vs 14% (adjusted hazard ratio 2.32, 95% CI: 1.11-4.85). In contrast, 10-year patient survival after the first KT was comparable to controls (93% vs 96%; 100% vs 94%, in groups 1 and 2, respectively). In summary, childhood cancer survivors’ KT was delayed, and their overall mortality when on KRT was increased, but once transplanted, their long-term outcome was similar to other KT recipients.
Item Description:Online verfügbar 7 November 2024, Version des Artikels 3 April 2025
Gesehen am 14.10.2025
Physical Description:Online Resource
ISSN:1600-6143
DOI:10.1016/j.ajt.2024.11.002

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