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Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis

Liver metastasis is observed in up to 50% of colorectal cancer (CRC) patients. Available treatment options are limited and disease recurrence is often. Chemokine receptor 5 (CCR5) has attracted attention as novel therapeutic target for treating cancers. In this study, we reinforced the importance of...

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Main Authors: Pervaiz, Asim (Author) , Zepp, Michael (Author) , Georges, Rania (Author) , Bergmann, Frank (Author) , Mahmood, Saqib (Author) , Faiza, Syeda (Author) , Berger, Martin R. (Author) , Adwan, Hassan (Author)
Format: Article (Journal)
Language:English
Published: January 2021
In: Journal of cancer research and clinical oncology
Year: 2021, Volume: 147, Issue: 1, Pages: 73-91
ISSN:1432-1335
DOI:10.1007/s00432-020-03382-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00432-020-03382-9
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00432-020-03382-9
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Author Notes:Asim Pervaiz, Michael Zepp, Rania Georges, Frank Bergmann, Saqib Mahmood, Syeda Faiza, Martin R. Berger, Hassan Adwan
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Summary:Liver metastasis is observed in up to 50% of colorectal cancer (CRC) patients. Available treatment options are limited and disease recurrence is often. Chemokine receptor 5 (CCR5) has attracted attention as novel therapeutic target for treating cancers. In this study, we reinforced the importance of CCR5 as therapeutic target in CRC and its liver metastasis by applying in vitro, in vivo and clinical investigations.
Item Description:Online publiziert: 09 September 2020
Gesehen am 20.10.2025
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-020-03382-9

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