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From experience to symptoms: a multilayer hierarchy of psychopathological dimensions in schizophrenia : phenomenological Psychopathology

Introduction: The psychopathology of schizophrenia is a complex amalgamation of features that span across different dimensions. These dimensions range from the experience of altered time and space through self-disorders to perceptual, positive, and negative symptoms. The relationship between these d...

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Main Authors: Lechner, Stephan (Author) , Sandsten, Karl Erik (Author) , Hirjak, Dusan (Author) , Daub, Jonas (Author) , Fritze, Stefan (Author) , Brandt, Geva A. (Author) , Arantes-Gonçalves, Filipe (Author) , Wolman, Angelika (Author) , Stefanelli, Riccardo (Author) , Gojer, Julian (Author) , Gulati, Sanjiv (Author) , Hersi, Hasan (Author) , Parnas, Josef (Author) , Northoff, Georg (Author)
Format: Article (Journal)
Language:English
Published: June 30, 2025
In: Psychopathology
Year: 2025, Pages: 1-19
ISSN:1423-033X
DOI:10.1159/000547153
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000547153
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Author Notes:Stephan Lechner, Karl Erik Sandsten, Dusan Hirjak, Jonas Daub, Stefan Fritze, Geva A. Brandt, Filipe Arantes-Gonçalves, Angelika Wolman, Riccardo Stefanelli, Julian Gojer, Sanjiv Gulati, Hasan Hersi, Josef Parnas, Georg Northoff
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Summary:Introduction: The psychopathology of schizophrenia is a complex amalgamation of features that span across different dimensions. These dimensions range from the experience of altered time and space through self-disorders to perceptual, positive, and negative symptoms. The relationship between these different psychopathological dimensions remains unclear. Addressing this gap was the aim of our study. Methods: We collected data on schizophrenia spectrum disorder at three medical expert centers, via semi-structured phenomenological interviews, consisting of the Scale for Space and Time Experience in Psychosis (STEP), the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and, for a subset of these data, the Examination of Anomalous Self-Experience (EASE), and the perceptual domain of the Bonn Scale for the Assessment of Basic Symptoms (BSABS or BONN). Various state-of-the-art statistical methods, including network and mediation analyses, were used to investigate the relationships between these psychopathological dimensions. Results: We found a relationship between altered time and space experiences (STEP) and both general symptoms (PANSS) and the basic self-disorders (EASE). Conclusion: Our various network and mediation analyses show that the basic self-disturbance is a key node in mediating the impact of the more fundamental time and space disturbances on both perceptual changes, and negative, positive, and general symptoms.
Item Description:Gesehen am 21.10.2025
Physical Description:Online Resource
ISSN:1423-033X
DOI:10.1159/000547153

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