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High fat diet induces gastric production of fibroblast growth factor 23 (FGF23)

A high fat diet (HFD) leads to lesions of the gastric epithelium and causes a proinflammatory environment. Fibroblast growth factor 23 (FGF23), a bone hormone, regulates renal phosphate and vitamin D metabolism. Under pathophysiological conditions production of FGF23 is stimulated. HFD feeding eleva...

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Bibliographic Details
Main Authors: Widmayer, Patricia (Author) , Feger, Martina (Author) , Meier, Leonie (Author) , Wagner, Andreas H. (Author) , Föller, Michael (Author)
Format: Article (Journal)
Language:English
Published: 07 June 2025
In: International journal of obesity
Year: 2025, Volume: 49, Issue: 9, Pages: 1733-1744
ISSN:1476-5497
DOI:10.1038/s41366-025-01808-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41366-025-01808-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41366-025-01808-3
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Author Notes:Patricia Widmayer, Martina Feger, Leonie Meier, Andreas H. Wagner and Michael Föller
Description
Summary:A high fat diet (HFD) leads to lesions of the gastric epithelium and causes a proinflammatory environment. Fibroblast growth factor 23 (FGF23), a bone hormone, regulates renal phosphate and vitamin D metabolism. Under pathophysiological conditions production of FGF23 is stimulated. HFD feeding elevates serum FGF23 levels through inflammation.
Item Description:Gesehen am 21.10.2025
Physical Description:Online Resource
ISSN:1476-5497
DOI:10.1038/s41366-025-01808-3

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