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Research communication: effects of screening colonoscopy on colorectal cancer mortality : lessons from comparative analyses of randomised trials

NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy t...

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Bibliographic Details
Main Authors: Brenner, Hermann (Author) , Sergeev, Dmitry (Author) , Heisser, Thomas (Author) , Hoffmeister, Michael (Author)
Format: Article (Journal) Editorial
Language:English
Published: Sep 2025
In: Alimentary pharmacology & therapeutics
Year: 2025, Volume: 62, Issue: 6, Pages: 656-659
ISSN:1365-2036
DOI:10.1111/apt.70231
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/apt.70231
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.70231
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Author Notes:Hermann Brenner, Dmitry Sergeev, Thomas Heisser, Michael Hoffmeister
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Summary:NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with those of NORCCAP, a similarly designed pragmatic sigmoidoscopy trial. In NORCCAP, differences in CRC mortality only began to emerge after 9.5 years of follow-up, rapidly increased thereafter and were approximately 4-fold as high after 12 years than after 10 years. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time.
Item Description:Gesehen am 22.10.2025
Physical Description:Online Resource
ISSN:1365-2036
DOI:10.1111/apt.70231

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