Cardiac regeneration: unraveling the complex network of intercellular crosstalk
The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardium and crosstalk between these cell types is crucial for proper cardiac function and homeostasis. In response to cardiac injury or disease, cell-cell...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 May 2025
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| In: |
Seminars in cell & developmental biology
Year: 2025, Volume: 171, Pages: 1-12 |
| ISSN: | 1096-3634 |
| DOI: | 10.1016/j.semcdb.2025.103619 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.semcdb.2025.103619 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1084952125000291 
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| Author Notes: | Bailin Wu, Florian Constanty, Arica Beisaw |
| Summary: | The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardium and crosstalk between these cell types is crucial for proper cardiac function and homeostasis. In response to cardiac injury or disease, cell-cell interactions and intercellular crosstalk contribute to remodeling to compensate reduced heart function. In some vertebrates, the heart can regenerate following cardiac injury. While cardiomyocytes play a crucial role in this process, additional cell types are necessary to create a pro-regenerative microenvironment in the injured heart. Here, we review recent literature regarding the importance of cellular crosstalk in promoting cardiac regeneration and provide insight into emerging technologies to investigate cell-cell interactions in vivo. Lastly, we explore recent studies highlighting the importance of inter-organ communication in response to injury and promotion of cardiac regeneration. Importantly, understanding how intercellular and inter-organ crosstalk promote cardiac regeneration is essential for the development of therapeutic strategies to stimulate regeneration in the human heart. |
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| Item Description: | Gesehen am 23.10.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1096-3634 |
| DOI: | 10.1016/j.semcdb.2025.103619 |