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Quantitative pupillometry as a sensitive biomarker for detecting subtle neurological impairment in mild traumatic brain injury: a pilot study

Mild traumatic brain injury accounts for roughly 55 million trauma cases globally each year. However, diagnosis and management remain challenging as conventional methods like cranial CT and the Glasgow Coma Scale do not reliably detect subtle neurological impairments. Quantitative Pupillometry has s...

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Main Authors: Mitschang, Dorothea (Author) , Sydorenko, Viktoriya (Author) , Kühlwein, Daniel (Author) , Beynon, Christopher (Author) , Younsi, Alexander (Author) , Krieg, Sandro (Author) , Lenga, Pavlina (Author)
Format: Article (Journal)
Language:English
Published: October 2025
In: Neurological sciences
Year: 2025, Volume: 46, Issue: 10, Pages: 5243-5251
ISSN:1590-3478
DOI:10.1007/s10072-025-08405-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10072-025-08405-2
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Author Notes:Dorothea Mitschang, Viktoriya Sydorenko, Daniel Kühlwein, Christopher Beynon, Alexander Younsi, Sandro M. Krieg, Pavlina Lenga
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Summary:Mild traumatic brain injury accounts for roughly 55 million trauma cases globally each year. However, diagnosis and management remain challenging as conventional methods like cranial CT and the Glasgow Coma Scale do not reliably detect subtle neurological impairments. Quantitative Pupillometry has shown promise in severe traumatic brain injury, but data on its use in mild traumatic brain injury is limited. This study aims to evaluate whether Quantitative Pupillometry can detect subtle neurological dysfunction in patients with mild traumatic brain injury.
Item Description:Online veröffenticht: 13. August 2025
Gesehen am 28.10.2025
Physical Description:Online Resource
ISSN:1590-3478
DOI:10.1007/s10072-025-08405-2

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